{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:01:16Z","timestamp":1761580876343,"version":"3.40.4"},"reference-count":27,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Objectives:&lt;\/i&gt; To determine whether caveolin-1 expression is associated with bladder pain syndrome\/interstitial cystitis (BPS\/IC) and to better understand the pathogenesis of BPS\/IC. &lt;i&gt;Methods:&lt;\/i&gt; The study population was composed of 19 women with BPS\/IC and 7 healthy women as controls. Midstream urine specimens were collected before cystoscopy and cold cup bladder biopsies were obtained from the trigone of the bladder. Caveolin-1 protein expression was determined by indirect immunofluorescence and Western blot analysis in cases and controls, using a rabbit polyclonal antibody against caveolin-1. \u03c7&lt;sup&gt;2&lt;\/sup&gt; test and Student\u2019s t test were used in the statistical analysis. &lt;i&gt;Results:&lt;\/i&gt; A statistical difference of caveolin-1 protein expression was observed between BPS\/IC and healthy controls (p &lt; 0.05, \u03c7&lt;sup&gt;2&lt;\/sup&gt; test). Western blot analysis showed that the mean relative integrated density value of caveolin-1 in (BPS\/IC) patients was significantly higher than that in the control group (p &lt; 0.001, Student\u2019s t test). &lt;i&gt;Conclusions:&lt;\/i&gt; The results of our study demonstrate that there is a relationship between the raised levels of caveolin-1 expression and BPS\/IC. This preliminary study may provide a basis for further investigation of the role of caveolin-1 in the pathogenesis of BPS\/IC.<\/jats:p>","DOI":"10.1159\/000323857","type":"journal-article","created":{"date-parts":[[2011,4,19]],"date-time":"2011-04-19T10:36:45Z","timestamp":1303209405000},"page":"334-339","source":"Crossref","is-referenced-by-count":5,"title":["Caveolin-1 May Participate in the Pathogenesis of Bladder Pain Syndrome\/ Interstitial Cystitis"],"prefix":"10.1159","volume":"86","author":[{"given":"Xia-Cong","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing-Hua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhan-Song","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gen-Sheng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,2,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2F00042307-200009000-00003"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.maturitas.2009.12.022"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159%2F000019679"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1152%2Fajpcell.00046.2005"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093%2Fcvr%2Fcvq075"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1152%2Fajplung.00488.2007"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.tcm.2005.11.007"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1582-4934.2007.00109.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1582-4934.2008.00331.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS1937-6448%2808%2901804-2"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1371%2Fjournal.pone.0011004"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00011-010-0157-9"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00192-009-0994-7"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.urology.2006.03.084"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007%2FBF01901246"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02765487"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.urology.2008.01.028"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00192-007-0515-5"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.juro.2009.07.013"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.urology.2009.09.078"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097%2F01.mou.0000232048.81965.16"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bbrc.2005.10.099"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1462-5822.2002.00230.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038%2F82176"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.272.30.18522"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1748-1716.2008.01907.x"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1024198518582"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/323857","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/323857","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:25:39Z","timestamp":1745436339000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000323857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":27,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,4,1]]},"published-print":{"date-parts":[[2011,4,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000323857","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"type":"print","value":"0042-1138"},{"type":"electronic","value":"1423-0399"}],"subject":[],"published":{"date-parts":[[2011]]}}}