{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T17:12:20Z","timestamp":1768929140041,"version":"3.49.0"},"reference-count":21,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; Total renal volume (TRV) is an important index to evaluate the progression of autosomal-dominant polycystic kidney disease (ADPKD). TRV has been assessed by manually tracing renal contours from CT or MR scans, often employing contrast medium (CM). We developed a fast and nearly automated technique based on the analysis of MR images acquired without CM injection for TRV quantification. &lt;i&gt;Methods:&lt;\/i&gt; 30 ADPKD patients underwent MRI. After the selection of one point inside each kidney for the entire volume, the automatic extraction of kidney contours was performed on each acquired slice; the segmentation procedure was based on region growing and on the application of morphological operators and curvature-based motion. The area inside each contour was calculated and TRV was derived. Volume measurements were validated by comparison with measurements obtained by stereology. &lt;i&gt;Results:&lt;\/i&gt; TRV estimated in patients was 768 \u00b1 545 ml (range 161\u20133,111 ml). The automatic measurements were in excellent correlation with the manual ones (r = 0.99, y = x \u2013 0.7), with a small bias and narrow limits of agreement in both absolute (\u20135 \u00b1 37 ml) and percentage (\u20130.6 \u00b1 9.6%) terms. &lt;i&gt;Conclusion:&lt;\/i&gt; This preliminary study showed the feasibility of a fast and nearly automated method for determining TRV; importantly it does not require the use of potentially nephrotoxic CM.<\/jats:p>","DOI":"10.1159\/000324039","type":"journal-article","created":{"date-parts":[[2011,2,10]],"date-time":"2011-02-10T07:57:26Z","timestamp":1297324646000},"page":"176-184","source":"Crossref","is-referenced-by-count":32,"title":["Assessment of Kidney Volume in Polycystic Kidney Disease Using Magnetic Resonance Imaging without Contrast Medium"],"prefix":"10.1159","volume":"33","author":[{"given":"Renzo","family":"Mignani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiana","family":"Corsi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariangela","family":"De Marco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico G.","family":"Caiani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gioele","family":"Santucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Cavagna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Severi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Cagnoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,2,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1992.195"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2215%2FCJN.03750708"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2215%2FCJN.00080605"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ki.5002624"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa054341"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMe068078"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2000.00433.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2215%2FCJN.02251205"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000092915"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10334-008-0158-7"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.2008.558"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.juro.2009.09.029"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2003.00185.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2006080835"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2215%2FCJN.00910306"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2F0730-725X%2886%2991068-4"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097%2F00004728-200007000-00019"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2894%2992026-5"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2FS0146-664X%2876%2980014-7"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038%2Fnrneph.2009.214"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMe1006925"}],"container-title":["American Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/324039","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/324039","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:27:03Z","timestamp":1745436423000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000324039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":21,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,3,1]]},"published-print":{"date-parts":[[2011,3,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000324039","archive":["Portico"],"relation":{},"ISSN":["0250-8095","1421-9670"],"issn-type":[{"value":"0250-8095","type":"print"},{"value":"1421-9670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}