{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:46:47Z","timestamp":1791294407239,"version":"4.1.0"},"reference-count":47,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; To confirm in a cohort recruited in 1999\u20132001 our finding in a cohort recruited in 1992\u20131994 relating type 2 diabetes (T2D) to late-onset Alzheimer\u2019s disease (LOAD). &lt;i&gt;Methods:&lt;\/i&gt; Participants were 1,488 persons aged 65 years and older without dementia at baseline from New York City. T2D was ascertained by self-report. Dementia and LOAD were ascertained by standard research procedures. Proportional hazard regression was used for analyses relating T2D and LOAD. &lt;i&gt;Results:&lt;\/i&gt; The prevalence of T2D was 17%. There were 161 cases of dementia and 149 cases of LOAD. T2D was related to dementia (hazard ratio = 1.7; 95% confidence interval = 1.4\u20132.9) and LOAD (1.6; 1.0\u20132.6) after adjustment for age, sex, education, ethnic group and apolipoprotein E &amp;#917;4. This association was weaker when only AD \u2013 excluding cases of mixed dementia \u2013 was considered (hazard ratio = 1.3; 95% confidence interval = 0.8\u20132.2). &lt;i&gt;Conclusion: &lt;\/i&gt;T2D is associated with LOAD. Cerebrovascular disease may be an important mediator.<\/jats:p>","DOI":"10.1159\/000324134","type":"journal-article","created":{"date-parts":[[2011,7,15]],"date-time":"2011-07-15T08:15:31Z","timestamp":1310717731000},"page":"424-430","source":"Crossref","is-referenced-by-count":117,"title":["Type 2 Diabetes and Late-Onset Alzheimer\u2019s 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