{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:37:32Z","timestamp":1745469452311,"version":"3.40.4"},"reference-count":17,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Neurol"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; The data on cerebrospinal fluid (CSF) levels of neurotrophins (NTs) in patients with meningoencephalitis are scarce, especially in adult patients. &lt;i&gt;Methods:&lt;\/i&gt; We measured CSF levels of NTs such as nerve growth factor (NGF), brain-derived neurotrophic factor, and neurotrophin-3 (NT-3) in adult patients with various meningitis (n = 10) and encephalitis (n = 10) in both acute phase and recovery phase and adult control subjects (n = 21) by the enzyme-linked immunosorbent assay for NTs. &lt;i&gt;Results:&lt;\/i&gt; Data show that NGF and NT-3 CSF levels were markedly elevated in the patient group in the acute phase compared with non-neurological controls (p &lt; 0.001 and p &lt; 0.05, respectively) and later returned to the levels of controls. Most intriguingly, we only recognized a significant correlation between NGF and NT-3 CSF levels in the patients in the acute phase. &lt;i&gt;Conclusion:&lt;\/i&gt; Such strong correlation of NGF and NT-3 CSF levels strongly suggests that in adult patients, some common regulatory mechanism(s) might be present among various kinds of NTs to cope with central nervous system infection.<\/jats:p>","DOI":"10.1159\/000324327","type":"journal-article","created":{"date-parts":[[2011,2,25]],"date-time":"2011-02-25T08:01:17Z","timestamp":1298620877000},"page":"138-143","source":"Crossref","is-referenced-by-count":11,"title":["Neurotrophin Levels in Cerebrospinal Fluid of Adult Patients with Meningitis and Encephalitis"],"prefix":"10.1159","volume":"65","author":[{"given":"Madoka","family":"Kizawa-Ueda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Kawamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomomasa","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eri","family":"Mutoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryouichi","family":"Shiroki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyotaka","family":"Hoshinaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiko","family":"Asakura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuro","family":"Mutoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,2,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.3306916"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2Fneu.480251103"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038%2F350158a0"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038%2F341149a0"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0169-328X%2897%2900021-1"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.tins.2005.07.003"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02736783"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2Fjnr.10760"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2F0959-4388%2895%2980048-4"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1006%2Fexnr.2000.7453"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3940%2899%2900463-2"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2F0955-2235%2894%2990018-3"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2F0896-6273%2891%2990273-3"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1007575504321"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1177%2F088307389701200310"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1651-2227.2004.tb02745.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002%2Fjnr.20176"}],"container-title":["European Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/324327","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/324327","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/324327","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:29:48Z","timestamp":1745436588000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000324327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":17,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,3,1]]},"published-print":{"date-parts":[[2011,3,23]]}},"URL":"https:\/\/doi.org\/10.1159\/000324327","archive":["Portico"],"relation":{},"ISSN":["0014-3022","1421-9913"],"issn-type":[{"type":"print","value":"0014-3022"},{"type":"electronic","value":"1421-9913"}],"subject":[],"published":{"date-parts":[[2011]]}}}