{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:56:51Z","timestamp":1780469811545,"version":"3.54.1"},"reference-count":20,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Aims:&lt;\/i&gt; We prospectively compared the effects of oral mycophenolate mofetil (MMF) or intravenous cyclophosphamide (IVC) combined with corticosteroids for induction therapy of microscopic polyangiitis (MPA) with renal involvement over a follow-up period of 6 months. &lt;i&gt;Methods:&lt;\/i&gt; 41 MPA patients were randomly assigned to either the open-label MMF group or the IVC group. Patients in the MMF group (n = 19) received oral MMF 1.0 g\/day (1.5 g\/day for patients with a body weight &gt;70 kg) and patients in the IVC group (n = 22) received IVC in monthly pulses of 1.0 g per pulse (0.8 g per pulse for patients with a body weight &lt;50 kg). Both groups received intravenous methylprednisolone 360\u2013500 mg\/day for 3 days, followed by oral prednisone 0.6\u20130.8 mg\/kg\/day and gradual tapering. &lt;i&gt;Results:&lt;\/i&gt; There was no significant difference of estimated glomerular filtration rate (eGFR) level between the IVC and MMF groups at baseline. At 6 months, the eGFR level increased significantly in both groups, but there was no significant difference between the two. Three patients in the IVC group and 1 in the MMF group received maintenance dialysis within 6 months (p = 0.36). The remission rate was 63.6% in the IVC group and 78.9% in the MMF group (p = 0.23). &lt;i&gt;Conclusion:&lt;\/i&gt; MMF is effective for inducing remission in Chinese MPA patients and may represent an alternative therapy to monthly impulses of IVC.<\/jats:p>","DOI":"10.1159\/000324364","type":"journal-article","created":{"date-parts":[[2011,2,11]],"date-time":"2011-02-11T08:38:52Z","timestamp":1297413532000},"page":"185-192","source":"Crossref","is-referenced-by-count":64,"title":["Effects of Mycophenolate Mofetil Combined with Corticosteroids for Induction Therapy of Microscopic Polyangiitis"],"prefix":"10.1159","volume":"33","author":[{"given":"Fei","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiayu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suya","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianghua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,2,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136%2Fpgmj.2005.034215"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2215%2FCJN.01461005"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093%2Frheumatology%2F39.6.585"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097%2FBOR.0b013e3282f370d1"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfi117"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000089667"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136%2Fard.2006.060301"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfm780"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.2215%2FCJN.06010809"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2Fart.20240"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2Fart.1780370206"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM198603063141004"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136%2Fard.2006.062711"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2007010090"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2F16.10.2018"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2002.00089.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097%2FMD.0b013e31817c744b"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2FS0009-9236%2898%2990102-3"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.2010.1658"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002%2Fart.10922"}],"container-title":["American Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/324364","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/324364","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:30:14Z","timestamp":1745436614000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000324364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":20,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,3,1]]},"published-print":{"date-parts":[[2011,3,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000324364","archive":["Portico"],"relation":{},"ISSN":["0250-8095","1421-9670"],"issn-type":[{"value":"0250-8095","type":"print"},{"value":"1421-9670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}