{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T19:29:39Z","timestamp":1769110179837,"version":"3.49.0"},"reference-count":21,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebrovasc Dis"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; In view of the increasing recognition of cerebral microbleeds (MCBs) with MRI, there is a need to validate their detection in post-mortem brains in patients with cerebrovascular diseases and dementia. &lt;i&gt;Materials and Methods:&lt;\/i&gt; Out of 20 post-mortem brains of patients with Alzheimer dementia and with different cerebrovascular lesions, 45 large sections of the cerebral hemispheres, brainstem and cerebellum were submitted to a 7.0-T T&lt;sub&gt;2&lt;\/sub&gt;*-weighted MRI, and afterwards compared to the histological detection of haematomas, MCBs and mini-bleeds (MNBs). &lt;i&gt;Results:&lt;\/i&gt; The sensitivity, specificity, predictive positive value and predictive negative value of the T&lt;sub&gt;2&lt;\/sub&gt;* imaging to detect MCBs and MNBs were excellent for those in the cortico-subcortical regions. There was a significant overestimation of MNBs in the striatum due to iron deposits unrelated to old haemorrhages. Also in the deep white matter, 42% of MNBs were not detected, while 31% of T&lt;sub&gt;2&lt;\/sub&gt;* hyposignals were not due to MNBs but to vessels filled with post-mortem thrombi. &lt;i&gt;Conclusions:&lt;\/i&gt; When evaluating the \u2018bleeding load\u2019 with 7.0-T T&lt;sub&gt;2&lt;\/sub&gt;*-weighted MRI in post-mortem brain sections of patients with dementia and vascular risk factors, only quantification of small cerebral bleeds in the cortico-subcortical regions is reliable.<\/jats:p>","DOI":"10.1159\/000324391","type":"journal-article","created":{"date-parts":[[2011,3,22]],"date-time":"2011-03-22T08:09:51Z","timestamp":1300781391000},"page":"511-517","source":"Crossref","is-referenced-by-count":67,"title":["Comparison of 7.0-T T&lt;sub&gt;2&lt;\/sub&gt;*-Magnetic Resonance Imaging of Cerebral Bleeds in Post-Mortem Brain Sections of Alzheimer Patients with Their Neuropathological Correlates"],"prefix":"10.1159","volume":"31","author":[{"given":"J.","family":"De Reuck","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Auger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Cordonnier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Deramecourt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Durieux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Pasquier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Bordet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.A.","family":"Maurage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Leys","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,3,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS1474-4422%2809%2970013-4"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.acra.2008.01.013"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1148%2Fradiol.2481071158"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.crad.2010.01.004"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1212%2F01.wnl.0000210535.20297.ae"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2Fawl387"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.30.8.1637"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1161%2Fhs0102.100885"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000139661"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00401-009-0615-z"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jns.2009.08.064"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jns.2010.09.031"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159%2F000092958"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.65.6.790"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3174%2Fajnr.A1355"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002%2Fjmri.22223"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159%2F000108522"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159%2F000151680"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159%2F000235850"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1179%2F174313209X382485"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00965616"}],"container-title":["Cerebrovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/324391","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/324391","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:30:44Z","timestamp":1745436644000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000324391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":21,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2011,4,1]]},"published-print":{"date-parts":[[2011,4,7]]}},"URL":"https:\/\/doi.org\/10.1159\/000324391","archive":["Portico"],"relation":{},"ISSN":["1015-9770","1421-9786"],"issn-type":[{"value":"1015-9770","type":"print"},{"value":"1421-9786","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}