{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:33:26Z","timestamp":1791221606584,"version":"4.1.0"},"reference-count":24,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Surg Res"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Glycine at high doses is known to protect the small intestine against ischemia-reperfusion (I\/R) injury. Here, we studied whether glycine at low clinically applicable doses has a protective effect. &lt;i&gt;Methods:&lt;\/i&gt; In series 1, intestinal I\/R was induced in male Wistar rats by occlusion (90 min)\/reopening (120 min) of the superior mesenteric artery. Glycine was intravenously infused for 30 min before ischemia (pre-ischemic infusion), and once again from 30 min before until 60 min after reperfusion. Total glycine doses applied over the 120-min infusion were 5, 10, 20, and 75 mg glycine\/kg. In series 2, pre-ischemic blood plasma glycine concentrations were determined under the conditions of series 1. &lt;i&gt;Results:&lt;\/i&gt; In series 1, attenuation of I\/R injury was comparable at 10, 20, and 75 mg glycine\/kg, but less at 5 mg\/kg (as indicated by less intestinal hemorrhages and better preserved mean arterial blood pressure, among other signs). In series 2, pre-ischemic blood plasma glycine concentrations increased with increasing glycine doses from 280 to 330, 340, 380, and 680 \u00b5&lt;i&gt;M&lt;\/i&gt;, respectively. &lt;i&gt;Conclusion:&lt;\/i&gt; These results demonstrate that even at a dose 50 times lower than previously applied \u2013 and at only slightly elevated plasma concentrations \u2013 glycine provides full protection against I\/R injury of the small intestine.<\/jats:p>","DOI":"10.1159\/000324393","type":"journal-article","created":{"date-parts":[[2011,3,31]],"date-time":"2011-03-31T07:05:33Z","timestamp":1301555133000},"page":"180-187","source":"Crossref","is-referenced-by-count":25,"title":["Protection from Glycine at Low Doses in Ischemia-Reperfusion Injury of the Rat Small 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