{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:37:39Z","timestamp":1745469459321,"version":"3.40.4"},"reference-count":12,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Dickkopf-1 (Dkk-1) glycoprotein is an inhibitor of the canonical Wnt pathway. Recent studies have demonstrated elevated Dkk-1 serum levels in patients with diverse malignancies. In vitro studies with melanoma cell lines showed that loss of Dkk-1 expression may contribute to tumor progression. &lt;i&gt;Objective:&lt;\/i&gt; The present study is the first in vivo investigation of Dkk-1 serum levels in patients with cutaneous malignant melanoma. &lt;i&gt;Methods:&lt;\/i&gt; We analyzed serum levels of Dkk-1 protein in 82 patients with cutaneous melanoma. &lt;i&gt;Results:&lt;\/i&gt; Serum levels were significantly increased (mean 83.01 pmol\/l) in comparison to healthy controls (mean 29.36 pmol\/l). No statistical difference in Dkk-1 serum levels neither between patients without or with lymph node metastases (p = 0.719) nor between patients with or without visceral metastases (p = 0.929) was found. Patients before excision had moderately higher Dkk-1 serum levels than after excision or with florid metastases. &lt;i&gt;Conclusion:&lt;\/i&gt; Our data suggest that increased Dkk-1 expression is an early event in melanoma, decreasing in later tumor stages. It was shown previously that Dkk-1 activates cell death in melanoma cells. Our in vivo data indicate that a decrease in Dkk-1 could be a sign of loss of tumor control.<\/jats:p>","DOI":"10.1159\/000324516","type":"journal-article","created":{"date-parts":[[2011,3,8]],"date-time":"2011-03-08T08:41:02Z","timestamp":1299573662000},"page":"171-175","source":"Crossref","is-referenced-by-count":7,"title":["Serum Levels of Glycoprotein Dickkopf-1 in Patients with Cutaneous Malignant Melanoma: A Prospective Pilot Study"],"prefix":"10.1159","volume":"222","author":[{"given":"Robert","family":"Feldmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Schierl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid M.","family":"Fink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul-Gunther","family":"Sator","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Maiweg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Steiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,3,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038%2F34848"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038%2Fjid.2008.445"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bbrc.2006.11.079"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.onc.1209508"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2008-03-145169"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2Fpros.20805"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jhep.2008.11.020"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2Fijc.22033"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2141.2006.06356.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1083%2Fjcb.200311122"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.jid.5700629"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1096%2Ffj.07-9475com"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/324516","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/324516","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:32:14Z","timestamp":1745436734000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000324516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":12,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,5,1]]},"published-print":{"date-parts":[[2011,5,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000324516","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"type":"print","value":"1018-8665"},{"type":"electronic","value":"1421-9832"}],"subject":[],"published":{"date-parts":[[2011]]}}}