{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T03:37:58Z","timestamp":1789443478387,"version":"build-2803163510"},"reference-count":15,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Neurol"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Sodium oxybate (SO; Xyrem\u00ae) has been approved in most countries for treatment of narcolepsy and cataplexy. In this study, we present a single-center experience of a series of 18 patients with narcolepsy with cataplexy (18\/18 DQB1*0602 positive, 17\/17 with low\/absent cerebrospinal fluid hypocretin) in whom SO was prescribed. After 26 \u00b1 13 months, 13\/18 patients were still on SO at a mean dosage of 6.1 \u00b1 1.2 g (in 8 of them in combination with stimulants). The following significant effects were observed: improved subjective sleepiness (12\/13), cataplexy (13\/13; median number of attacks from 20 to 1\/month), hallucinations (8\/10) and sleep paralysis (8\/8); increase in mean sleep latency on the Maintenance of Wakefulness Test (from 5.5 to 17.4 min) and sleep\/rest efficiency on actigraphy (from 61 to 76%); decrease in Epworth Sleepiness Scale score (from 18 to 14), sleep onset REM periods on the Multiple Sleep Latency Test (from 3.6 to 2.4) and errors in the Steer-Clear Test (from 11 to 2%). Five patients discontinued SO because of insufficient compliance (n = 2), lack of efficiency (n = 1) and side effects (n = 1). These data confirm and expand previous reports on the good effects and tolerability of SO as a treatment for narcolepsy with cataplexy.<\/jats:p>","DOI":"10.1159\/000324549","type":"journal-article","created":{"date-parts":[[2011,3,8]],"date-time":"2011-03-08T08:42:30Z","timestamp":1299573750000},"page":"175-182","source":"Crossref","is-referenced-by-count":27,"title":["Sodium Oxybate in Narcolepsy with Cataplexy: Zurich Sleep Center Experience"],"prefix":"10.1159","volume":"65","author":[{"given":"R.","family":"Poryazova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Tartarotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Khatami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.R.","family":"Baumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Valko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Kallweit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Werth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.L.","family":"Bassetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,3,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0733-8619%2805%2970273-5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-5728%2801%2900333-2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.59.10.1553"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2F0024-3205%2887%2990721-1"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2F0006-2952%2884%2990629-4"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2F0013-4694%2867%2990064-8"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2F0006-3223%2889%2990048-6"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-44-5-1014"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.sleep.2009.01.005"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.sleep.2009.08.003"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.sleep.2003.11.002"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.sleep.2005.03.010"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1468-1331.2006.01473.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.108.3.619"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.sleep.2009.05.004"}],"container-title":["European Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/324549","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/324549","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/324549","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:32:32Z","timestamp":1745422352000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000324549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":15,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,3,1]]},"published-print":{"date-parts":[[2011,3,23]]}},"URL":"https:\/\/doi.org\/10.1159\/000324549","archive":["Portico"],"relation":{},"ISSN":["0014-3022","1421-9913"],"issn-type":[{"value":"0014-3022","type":"print"},{"value":"1421-9913","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}