{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T05:57:50Z","timestamp":1773381470214,"version":"3.50.1"},"reference-count":24,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; Contrast-induced nephropathy (CIN) remains a leading cause of iatrogenic acute renal failure. Terlipressin, a long-acting analog of vasopressin, may improve renal function. This study aimed to investigate the possible protective effect of terlipressin against the development of experimental CIN in rats. &lt;i&gt;Methods:&lt;\/i&gt; Wistar albino rats (n = 32) were allocated randomly into four equal groups of 8 each, i.e. control, terlipressin, contrast media (CM), and terlipressin plus contrast media (TCM). CIN was induced by intravenous administration of indomethacin (10 mg\/kg), N-nitro &lt;i&gt;L&lt;\/i&gt;-arginine methyl ester (&lt;i&gt;L&lt;\/i&gt;-NAME, 10 mg\/kg, twice at 15 and 30 min), and high-osmolar contrast media meglumine amidotrizoate 60%. Renal function parameters, kidney histology, and tubular expression of vascular endothelial growth factor (VEGF) were determined. &lt;i&gt;Results:&lt;\/i&gt; Mean serum creatinine levels were decreased (p &lt; 0.05) and creatinine clearance (p &lt; 0.05) increased in the TCM group compared with the CM group. Notably, rats in the TCM group displayed less tubular necrosis (p &lt; 0.05), medullary congestion (p &lt; 0.05), and a reduced tubular expression of VEGF (p &lt; 0.05) compared with the CM group. &lt;i&gt;Conclusion:&lt;\/i&gt; These results demonstrate that terlipressin can inhibit the development of CIN.<\/jats:p>","DOI":"10.1159\/000324764","type":"journal-article","created":{"date-parts":[[2011,3,8]],"date-time":"2011-03-08T13:42:30Z","timestamp":1299591750000},"page":"269-276","source":"Crossref","is-referenced-by-count":11,"title":["Protective Effect of the Vasopressin Agonist Terlipressin in a Rat Model of Contrast-Induced Nephropathy"],"prefix":"10.1159","volume":"33","author":[{"given":"Elif","family":"Ari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuf","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alla 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