{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:37:46Z","timestamp":1745469466329,"version":"3.40.4"},"reference-count":10,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; To report pancytopenia caused by temozolomide, a second-generation alkylating agent. &lt;i&gt;Clinical Presentation and Intervention:&lt;\/i&gt; A 22-year-old patient presenting with seizures and confusion was seen in the emergency room. Cranial magnetic resonance imaging revealed a mass. After surgery, the patient was diagnosed with glioblastoma multiforme and was given temozolomide at 150 mg\/m&lt;sup&gt;2&lt;\/sup&gt; on days 1 through 5 every 4 weeks. During the last cycle of temozolomide, grade 3 thrombocytopenia persisted. Possible causes of pancytopenia including vitamin B&lt;sub&gt;12&lt;\/sub&gt; deficiency were investigated.&lt;i&gt; Conclusion:&lt;\/i&gt; This case report shows that vitamin B&lt;sub&gt;12&lt;\/sub&gt; deficiency can be a potential cause of pancytopenia and it should be kept in mind for patients receiving chemotherapy.<\/jats:p>","DOI":"10.1159\/000324800","type":"journal-article","created":{"date-parts":[[2011,5,12]],"date-time":"2011-05-12T06:42:09Z","timestamp":1305182529000},"page":"377-379","source":"Crossref","is-referenced-by-count":0,"title":["Another Cause of Pancytopenia in a Patient Receiving Temozolomide"],"prefix":"10.1159","volume":"20","author":[{"given":"Yavuz","family":"Pehlivan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alper","family":"Sevinc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim Halil","family":"Turkbeyler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"Dirier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Emin","family":"Kalender","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celalettin","family":"Camci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,5,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1517%2F14656566.8.18.3133"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200108233450817"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.23859"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1008354323167"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2002.04.140"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa043330"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1188%2F03.CJON.S6.11-19"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS1470-2045%2806%2970696-9"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11060-007-9403-6"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11060-008-9754-7"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/324800","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/324800","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:34:58Z","timestamp":1745436898000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000324800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":10,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2011,5,1]]},"published-print":{"date-parts":[[2011,5,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000324800","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"type":"print","value":"1011-7571"},{"type":"electronic","value":"1423-0151"}],"subject":[],"published":{"date-parts":[[2011]]}}}