{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T12:43:40Z","timestamp":1785329020625,"version":"3.55.0"},"reference-count":19,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2011]]},"abstract":"<i>Background:<\/i> The aim of this study is to investigate tubular and glomerular function after visceral leishmaniasis (VL) treatment with pentavalent antimonials. <i>Methods:<\/i> This is a prospective study including 14 patients with VL diagnosis treated with pentavalent antimonials. Urine acidification and concentration tests were performed. Estimated glomerular filtration rate (eGFR), fractional excretion of sodium (FE<sub>Na<\/sub>) and potassium (FE<sub>K<\/sub>) and free water clearance (C<sub>H2O<\/sub>) were measured to assess glomerular and tubular function. <i>Results:<\/i> The VL group had a significantly lower FE<sub>K<\/sub>, serum sodium and plasma osmolality (P<sub>osm<\/sub>). No significant differences were found regarding proteinuria, eGFR, FE<sub>Na<\/sub> or C<sub>H2O<\/sub>. Patients in the VL group had lower urinary osmolality (U<sub>osm<\/sub>) before DDAVP use when compared to the control group, as well as a lower U\/P<sub>osm<\/sub>. The urinary pH before and after CaCl<sub>2<\/sub> load was higher in the VL group. <i>Conclusion:<\/i> This study shows evidence of reversal of some tubular dysfunction in VL, but other dysfunctions may persist, especially urinary acidification capacity.<\/jats:p>","DOI":"10.1159\/000324914","type":"journal-article","created":{"date-parts":[[2011,3,11]],"date-time":"2011-03-11T08:03:22Z","timestamp":1299830602000},"page":"332-336","source":"Crossref","is-referenced-by-count":12,"title":["Renal Function Improvement with Pentavalent Antimonial Agents in Patients with Visceral Leishmaniasis"],"prefix":"10.1159","volume":"33","author":[{"given":"Elizabeth F.","family":"Daher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e1lia A.","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle J.C.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz F.L.G.","family":"Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jobson L.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldo B.","family":"Silva Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krasnalhia L\u00edvia S.","family":"Abreu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme A.L.","family":"Henn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice M.C.","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre B.","family":"Lib\u00f3rio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,3,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfi157"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS1473-3099%2802%2900347-X"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2898%2910178-2"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS1473-3099%2805%2970296-6"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1590%2FS0037-86822003000200004"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.4269%2Fajtmh.2010.09-0571"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1590%2FS1413-86702008000400015"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1258%2Ftd.2008.080369"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1708-8305.2008.00220.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfg267"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2337%2Fdiabetes.39.7.761"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159%2F000184066"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159%2F000180458"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.286.4.421"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.1999.00232.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1990.266"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa042743"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097%2F00005792-196701000-00003"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1053%2Fajkd.2002.32764"}],"container-title":["American Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/324914","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/324914","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:35:33Z","timestamp":1745436933000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000324914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":19,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2011,4,1]]},"published-print":{"date-parts":[[2011,4,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000324914","archive":["Portico"],"relation":{},"ISSN":["0250-8095","1421-9670"],"issn-type":[{"value":"0250-8095","type":"print"},{"value":"1421-9670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}