{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T16:10:00Z","timestamp":1759421400493,"version":"3.40.4"},"reference-count":27,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[2011]]},"abstract":"<i>Background:<\/i> Patients with atherosclerotic renovascular disease (ARVD) have a high risk of cardiovascular death. The primary aim was to characterize abnormalities in apolipoprotein (Apo)-defined lipoprotein (Lp) subclasses in patients with ARVD. <i>Methods:<\/i> Baseline measurements were performed on 42 patients with ARVD 4 weeks after renal angioplasty (PTRA). All patients were on statin treatment. Twenty age-matched healthy subjects without medications served as controls. Subsequently, patients were randomized to treatment with either candesartan (n = 21), or antihypertensive treatment without inhibitors of the renin-angiotensin-aldosterone system (n = 21) and followed for 11 months. <i>Results:<\/i> At baseline, ApoC-III (12.7 \u00b1 4.6 vs. 8.8 \u00b1 2.6 (SD) mg\/dl, p < 0.05), LpB:C:E (13.3 \u00b1 5.4 vs. 8.4 \u00b1 4.3 mg\/dl, p < 0.05), and the sum of ApoC-III-containing lipoproteins, i.e. LpB:C + LpB:C:E + LpA-II:B:C:D:E (46 \u00b1 15 vs. 37 \u00b1 8 mg\/dl, p < 0.05), were significantly elevated in ARVD patients versus healthy controls. Multiple regression analyses showed that only plasma renin activity was independently associated with ApoC-III levels at baseline (p < 0.05, r = 0.74). Treatment with candesartan did not correct abnormalities. <i>Conclusions:<\/i> Patients with ARVD treated with statins have an atherogenic lipoprotein profile characterized by elevated levels of ApoC-III-containing, triglyceride-rich lipoproteins that could accelerate atherosclerotic disease.<\/jats:p>","DOI":"10.1159\/000325648","type":"journal-article","created":{"date-parts":[[2011,5,26]],"date-time":"2011-05-26T06:43:34Z","timestamp":1306392214000},"page":"311-319","source":"Crossref","is-referenced-by-count":2,"title":["Lipoprotein Abnormalities in Patients with Atherosclerotic Renovascular Disease"],"prefix":"10.1159","volume":"34","author":[{"given":"Elzbieta","family":"Nowakowska 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