{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T17:16:22Z","timestamp":1792343782341,"version":"4.4.0"},"reference-count":15,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Introduction:&lt;\/i&gt; Bladder augmentation predisposes humans to many metabolic, renal and enteropatch changes. Our aim was to evaluate in a rat model of ileocystoplasty mid- and long-term urinary, metabolic, renal and graft changes. &lt;i&gt;Materials and Methods:&lt;\/i&gt; We performed an ileocystoplasty and a sham operation in 30 rats. Seven augmented rats and 3 sham-operated animals were euthanized after 1, 3 and 6 months. We performed urinalysis, urine culture and blood sampling for serum electrolytes and urea. Histopathological changes of the ileal patch and kidneys were also evaluated. &lt;i&gt;Results:&lt;\/i&gt; The urine cultures were positive in 14.3, 57 and 71%, respectively, 1, 3 and 6 months after surgery. Urinary pH, serum chloride and urea of the augmented group were significantly higher. Bladder calculi were formed in 23.8% of ileocystoplasty. Histopathological examination showed urothelialization of the graft with hyperplastic\/metaplastic changes. The kidneys showed glomerular depletion and a marked distal tubular ectasia. &lt;i&gt;Conclusions:&lt;\/i&gt; Our data showed that, in a mid- and long-term follow-up, rat bladders subjected to ileocystoplasty displayed hyperchloremic metabolic acidosis, electrolyte imbalance, enhanced serum blood urea levels and glomerular\/tubular changes. Hyperplastic and\/or metaplastic changes at the junctional zone were observed. Our experimental results suggest that frequent monitoring of renal function and surveillance of humans who have undergone ileocystoplasty are recommended.<\/jats:p>","DOI":"10.1159\/000325944","type":"journal-article","created":{"date-parts":[[2011,8,4]],"date-time":"2011-08-04T18:41:03Z","timestamp":1312483263000},"page":"87-93","source":"Crossref","is-referenced-by-count":1,"title":["Ileocystoplasty in Rats: Metabolic, Renal and Enteropatch Changes in a Mid- and Long-Term Follow-Up"],"prefix":"10.1159","volume":"87","author":[{"given":"Salvatore","family":"Arena","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Arena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine","family":"Fazzari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letteria","family":"Minutoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Russo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenica","family":"Altavilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Squadrito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero Antonio","family":"Nic\u00f2tina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmelo","family":"Romeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Magno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,6,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0090-4295%2899%2900443-4"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2Fnau.1930140304"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1464-410X.1985.tb06366.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-5347%2801%2968080-7"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1464-410X.2003.04000.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-5347%2805%2966978-9"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1464-410X.2002.03035.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-5347%2801%2965556-3"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1442-2042.2004.00749.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-5347%2801%2967198-2"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097%2F00005392-199907000-00075"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1464-410x.2000.00769.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002%2Fbjs.1800781021"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093%2Fcarcin%2F10.9.1733"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0094-0143%2805%2970414-6"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/325944","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/325944","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:58:14Z","timestamp":1745434694000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000325944"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2011,8,1]]},"published-print":{"date-parts":[[2011,8,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000325944","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}