{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:35:58Z","timestamp":1745469358155,"version":"3.40.4"},"reference-count":19,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2011]]},"abstract":"<i>Background:<\/i> Adequate nutritional intake is essential in the very-low-birth-weight infant, but difficult to achieve in the first few postnatal days. Can lipids be given enterally in the first few days of life in sick preterm infants? <i>Objective:<\/i> To determine tolerance and absorption of lipid emulsion when fed enterally to very-low-birth-weight infants. <i>Design\/Methods:<\/i> Infants had a birth weight <1,500 g, an appropriate weight for gestational age, and were receiving parenteral nutrition. We performed a progressive series of studies, enrolling 5 infants in each group. Group 1 infants were fed enteral lipid emulsion at 1 g\/kg\/day for 4 days, starting when 60 ml\/kg\/day of breast milk was tolerated enterally. Simultaneously, a matched control group which received no oral lipid emulsion was enrolled. We then enrolled group 2 infants who were fed 3 g\/kg\/day with the same protocol as group 1. Group 3 infants were fed enteral lipid emulsion starting in the first 72 h of life. The infants were fed 1, 2 and 3 g\/kg\/day subsequently for 48 h each. Fat absorption was measured. <i>Results:<\/i> Gestational age was 24.6\u201330.8 weeks and birth weight was 620\u20131,400 g. One infant (group 1) developed necrotizing enterocolitis 1 week after the study. There were no other adverse clinical findings. On average, enteral lipid emulsion was started on day 8 of life in groups 1 and 2, and on day 2 in group 3. The intestinal lipid absorption was 93.6% (min. = 76%). There was no difference in fat absorption between the 4 groups (p > 0.05). <i>Conclusions:<\/i> Lipid emulsions are an isotonic high-calorie source which can be given safely enterally instead of intravenously in the immediate neonatal period of very-low-birth-weight infants without clinical adverse effects and with almost complete absorption. There are potential advantages to oral administration of a lipid emulsion starting in early life which require further investigation.<\/jats:p>","DOI":"10.1159\/000326079","type":"journal-article","created":{"date-parts":[[2011,6,22]],"date-time":"2011-06-22T13:57:55Z","timestamp":1308751075000},"page":"248-252","source":"Crossref","is-referenced-by-count":1,"title":["Intestinal Absorption of Lipid Emulsion in Premature Infants: A Pilot Study"],"prefix":"10.1159","volume":"100","author":[{"given":"A.","family":"Janvier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Beaumier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.J.","family":"Barrington","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,6,22]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1542%2Fpeds.2008-0211"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1136%2Fadc.2001.004044"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1203%2F00006450-199810000-00005"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1016%2F0009-8981%2867%2990029-0"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1159%2F000276979"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1016%2FS0022-3476%2805%2982416-3"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1016%2FS0022-3476%2888%2980587-0"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1016%2FS0022-3476%2805%2980397-X"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1136%2Fadc.74.2.95"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1203%2F00006450-198712000-00021"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.1177%2F0148607185009002144"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.1203%2F00006450-199302000-00002"},{"doi-asserted-by":"publisher","key":"ref13","DOI":"10.1016%2FS0022-3476%2875%2980983-8"},{"doi-asserted-by":"publisher","key":"ref14","DOI":"10.1097%2F00003246-199611000-00021"},{"doi-asserted-by":"publisher","key":"ref15","DOI":"10.1063%2F1.344382"},{"doi-asserted-by":"publisher","key":"ref16","DOI":"10.1139%2Fy01-042"},{"doi-asserted-by":"publisher","key":"ref17","DOI":"10.1542%2Fpeds.103.2.434"},{"doi-asserted-by":"publisher","key":"ref18","DOI":"10.1136%2Fadc.77.1.4"},{"doi-asserted-by":"publisher","key":"ref19","DOI":"10.1097%2F00005176-199208000-00011"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/326079","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/326079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:59:52Z","timestamp":1745434792000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000326079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":19,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,9,1]]},"published-print":{"date-parts":[[2011,9,15]]}},"URL":"https:\/\/doi.org\/10.1159\/000326079","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"type":"print","value":"1661-7800"},{"type":"electronic","value":"1661-7819"}],"subject":[],"published":{"date-parts":[[2011]]}}}