{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:27:52Z","timestamp":1791167272799,"version":"4.1.0"},"reference-count":26,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; The causes of bronchopulmonary dysplasia (BPD) are multifactorial. Overdistension of the lung (volutrauma) is considered an important contribution. As an alternative to traditional pressure-limited ventilation (PLV), modern neonatal ventilators offer modes which can target a set tidal volume. &lt;i&gt;Objectives:&lt;\/i&gt; To determine whether volume-targeted neonatal ventilation, compared with PLV, reduces death or BPD. &lt;i&gt;Methods:&lt;\/i&gt; We performed a systematic review and meta-analysis using the methodology of the Neonatal Review Group of the Cochrane Collaboration. A comprehensive literature search was undertaken, and data for prespecified outcomes were combined where appropriate using the fixed effects model. &lt;i&gt;Results:&lt;\/i&gt; Nine trials were eligible. Volume-targeted ventilation resulted in a reduction in: the combined outcome of death or BPD [typical relative risk, RR, 0.73 (95% confidence interval, 0.57\u20130.93), numbers needed to treat, NNT, 8 (95% CI 5\u201333)], the incidence of pneumothorax [typical RR 0.46 (95% CI 0.25\u20130.84), NNT 17 (95% CI 10\u2013100)], days of ventilation [weighted mean difference 0.8 days (log-transformed data, p = 0.05)], hypocarbia (pCO&lt;sub&gt;2&lt;\/sub&gt; &lt;35 mm Hg\/4.7 kPa); [typical RR 0.56 (95% CI 0.33\u20130.96), NNT 4 (95% CI 2\u201325)], and the combined outcome of periventricular leukomalacia or grade 3\u20134 intraventricular hemorrhage [typical RR 0.48 (95% CI 0.28\u20130.84), NNT 11 (95% CI 7\u201350)]. &lt;i&gt;Conclusions:&lt;\/i&gt; Compared with PLV, infants ventilated using volume-targeted ventilation had reduced death\/BPD, duration of ventilation, pneumothoraces, hypocarbia and periventricular leukomalacia\/severe intraventricular hemorrhage. Further studies are needed to assess neurodevelopmental outcomes.<\/jats:p>","DOI":"10.1159\/000326080","type":"journal-article","created":{"date-parts":[[2011,6,22]],"date-time":"2011-06-22T13:57:55Z","timestamp":1308751075000},"page":"219-227","source":"Crossref","is-referenced-by-count":98,"title":["Volume-Targeted versus Pressure-Limited Ventilation for Preterm Infants: A Systematic Review and Meta-Analysis"],"prefix":"10.1159","volume":"100","author":[{"given":"Kevin I.","family":"Wheeler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Klingenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin J.","family":"Morley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter G.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,6,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-199709000-00016"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1067%2Fmpd.2001.118201"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI110400"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2Fppul.20063"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2800%2904934-5"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007%2Fs001340050441"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.2008.150938"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.earlhumdev.2006.05.013"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001%2Farchpedi.159.9.868"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2Fppul.10458"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.jp.7211233"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136%2Ffn.77.3.F202"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jpeds.2006.01.044"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038%2Fjp.2009.11"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159%2F000209301"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.2006.113464"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.2009.181081"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.276.16.1332"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199708213370806"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1651-2227.2007.00388.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jpeds.2010.05.043"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002%2Fppul.1091"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002%2Fppul.20667"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1440-1754.2002.00041.x"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1159%2F000047090"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clp.2006.06.012"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/326080","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/326080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:59:53Z","timestamp":1745434793000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000326080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":26,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,9,1]]},"published-print":{"date-parts":[[2011,9,15]]}},"URL":"https:\/\/doi.org\/10.1159\/000326080","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}