{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:34:31Z","timestamp":1761597271462,"version":"3.40.4"},"reference-count":17,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2011,5,10]],"date-time":"2011-05-10T00:00:00Z","timestamp":1304985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,5,10]],"date-time":"2011-05-10T00:00:00Z","timestamp":1304985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Serum levels of pneumocyte biomarkers KL-6 and surfactant protein D (SP-D) are useful diagnostic markers for interstitial lung diseases. However, associations of serum KL-6 and SP-D with radiologic findings in nonspecific interstitial pneumonia (NSIP) remain unclear. &lt;i&gt;Objectives:&lt;\/i&gt; To determine whether serum levels of KL-6 and SP-D reflect fibrotic and\/or inflammatory processes in NSIP, we investigated the correlation between high-resolution computed tomography (HRCT) findings and serum KL-6 and SP-D levels. &lt;i&gt;Methods:&lt;\/i&gt; Serum levels of KL-6 and SP-D were measured in 21 patients with biopsy-confirmed NSIP. The radiographic extent of 6 HRCT patterns and total HRCT score, defined as the scored fibrotic index, were assessed. Changes in the levels of serum markers and CT findings during follow-up were also monitored. &lt;i&gt;Results:&lt;\/i&gt; Serum levels of KL-6 in NSIP positively correlated with the total HRCT score and overall extent of interstitial disease. Serum levels of SP-D in NSIP showed a positive correlation with the area of ground-glass attenuation without traction bronchiectasis and the inflammatory CT pattern, but the levels were inversely correlated with the area of ground-glass attenuation with traction bronchiectasis and the fibrotic CT pattern. The follow-up CT and serum marker changes after treatment showed that percent change of disease extent was reflected in both markers, especially KL-6. Further, the decreased fibrotic pattern correlated with both biomarkers. &lt;i&gt;Conclusions:&lt;\/i&gt; The results indicate that serum levels of KL-6 in NSIP reflect the overall extent of interstitial lesions, which include both inflammatory and fibrotic lesions, while the levels of SP-D mainly reflect the extent of inflammatory lesions.<\/jats:p>","DOI":"10.1159\/000326924","type":"journal-article","created":{"date-parts":[[2011,5,10]],"date-time":"2011-05-10T06:52:17Z","timestamp":1305010337000},"page":"190-197","source":"Crossref","is-referenced-by-count":28,"title":["Pneumocyte Biomarkers KL-6 and Surfactant Protein D Reflect the Distinct Findings of High-Resolution Computed Tomography in Nonspecific Interstitial Pneumonia"],"prefix":"10.1159","volume":"83","author":[{"given":"Hidenori","family":"Ichiyasu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Ichikado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihisa","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Iyonaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moritaka","family":"Suga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotsugu","family":"Kohrogi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,5,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2F00000478-200001000-00003"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1513%2Fpats.200601-005TK"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.200611-1685OC"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159%2F000225987"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097%2F00000478-199402000-00003"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1148%2Fradiol.2251011555"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1148%2Frg.235035702"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.96.1.68"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.02.00081102"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.rmed.2009.08.011"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1259%2Fbjr%2F72775434"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.2106157"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1440-1843.2006.00834.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.98.12051010"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.crad.2004.06.029"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136%2Fthorax.58.1.52"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097%2F00004728-200001000-00008"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/326924","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/326924","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:08:53Z","timestamp":1745435333000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000326924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,10]]},"references-count":17,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,2,1]]},"published-print":{"date-parts":[[2012,2,15]]}},"URL":"https:\/\/doi.org\/10.1159\/000326924","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"type":"print","value":"0025-7931"},{"type":"electronic","value":"1423-0356"}],"subject":[],"published":{"date-parts":[[2011,5,10]]}}}