{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:51:38Z","timestamp":1787017898016,"version":"build-2736575974"},"reference-count":22,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2011,5,11]],"date-time":"2011-05-11T00:00:00Z","timestamp":1305072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,5,11]],"date-time":"2011-05-11T00:00:00Z","timestamp":1305072000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2012]]},"abstract":"<i>Background:<\/i> Eosinophilic pleural effusion (EPE) is defined by an eosinophil count of \u226710% in the pleural fluid and often caused by air or blood in the pleural space. The diagnostic significance of EPEs is still a matter of debate. <i>Objective:<\/i> The objective of this study was to systematically review the medical literature to evaluate the diagnostic significance of EPEs. <i>Methods:<\/i> Electronic databases were searched from 1950 to April 2010 to perform a meta-analysis. Data were extracted using standardized forms, and pooled odds ratios with 95% confidence intervals were calculated. A logistic regression analysis was also performed to evaluate the association between the pleural eosinophil counts and the likelihood of underlying causes of EPEs. <i>Results:<\/i> We identified a total of 687 cases of EPE. The most common cause of EPEs was malignancy (26%) followed by idiopathic (25%) and parapneumonic (13%) effusions. The likelihood of malignancy or tuberculosis was somehow lower in EPEs than in non-EPEs, but the differences were not statistically significant. The prevalence of malignancy was significantly lower in the group of patients that required a pathologic confirmation (21 vs. 30%; p = 0.01). The likelihood of malignancy was inversely correlated with the pleural fluid eosinophil counts. The likelihood of idiopathic effusion was significantly higher in EPEs than in non-EPEs. <i>Conclusions:<\/i> Malignancy was the most common cause of EPEs. EPEs appeared to be a negative predictor of malignancy when a pleural fluid eosinophil count was extremely high. EPEs were more likely to be idiopathic as compared with non-EPEs.<\/jats:p>","DOI":"10.1159\/000327200","type":"journal-article","created":{"date-parts":[[2012,2,15]],"date-time":"2012-02-15T05:09:22Z","timestamp":1329282562000},"page":"198-208","source":"Crossref","is-referenced-by-count":55,"title":["The Prevalence and Diagnostic Significance of Eosinophilic Pleural Effusions: A Meta-Analysis and Systematic Review"],"prefix":"10.1159","volume":"83","author":[{"given":"Yuji","family":"Oba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tareq","family":"Abu-Salah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,5,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2F00063198-200307000-00002"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.122.2.576"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2F01.mcp.0000127902.37822.13"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9343%2884%2990542-4"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.00.15116600"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.110.5.1271"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1371%2Fjournal.pmed.0040297"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2F0895-4356%2894%2900106-Z"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.327.7414.557"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0258%2819990215%2918%3A3%3C321%3A%3AAID-SIM28%3E3.0.CO%3B2-P"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.315.7121.1533"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.0954-6820.1981.tb09788.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159%2F000194802"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.96.5.992"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002%2Fdc.10227"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159%2F000325841"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.00197708"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1001%2Farchinte.132.6.854"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1136%2Fthx.34.1.106"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.127.3.1017"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.124.3.978"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.116.1.212"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/327200","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/327200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:11:35Z","timestamp":1745421095000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000327200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,11]]},"references-count":22,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,2,1]]},"published-print":{"date-parts":[[2012,2,15]]}},"URL":"https:\/\/doi.org\/10.1159\/000327200","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,11]]}}}