{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:16:45Z","timestamp":1758633405874,"version":"3.40.4"},"reference-count":22,"publisher":"S. Karger AG","issue":"Suppl. 1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2011]]},"abstract":"<i>Background:<\/i> Peroxisome proliferator-activated receptor-\u03b3 (PPAR\u03b3) is a member of the nuclear receptors, which regulate fatty acid metabolites. One of the natural ligands for PPAR\u03b3 is 15-deoxy-\u0394<sup>12,14<\/sup>-prostaglandin J<sub>2<\/sub> (15d-PGJ<sub>2<\/sub>), a major metabolite of prostaglandin D<sub>2<\/sub> (PGD<sub>2<\/sub>). Recently, PPAR\u03b3 has been shown to play an important role in anti-inflammatory reactions, including within-airway allergic diseases, in a mouse model. Our aim was to clarify the expression and localization of PPAR\u03b3 and PGD<sub>2<\/sub> synthase, which produces ligands of PPAR\u03b3, in nasal polyps by immunohistochemical analysis. <i>Methods:<\/i> Nasal polyps of chronic rhinosinusitis patients (6 asthmatic patients and 6 nonasthmatic patients) were obtained during surgery. May-Gr\u00fcnwald-Giemsa staining was performed to evaluate the eosinophil infiltration of the polyps. To identify the cells expressing PPAR\u03b3 protein and PGD<sub>2<\/sub> synthase, double immunostaining was performed using anti-PPAR\u03b3 antibody, monoclonal antileukocyte antibodies, and PGD<sub>2<\/sub> synthase antibody. <i>Results:<\/i> The number of eosinophils and the number of PPAR\u03b3-positive cells in the nasal polyps of the asthmatic patients were significantly higher than those in the nonasthmatic patients. PPAR\u03b3 was expressed on eosinophils and T cells of the infiltrating cells in the nasal polyps. PGD<sub>2<\/sub> synthase was also expressed on PPAR\u03b3-positive cells. <i>Conclusion:<\/i> PPAR\u03b3 is involved in nasal polyposis pathogenesis, acting on eosinophils and T cells.<\/jats:p>","DOI":"10.1159\/000327294","type":"journal-article","created":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T07:54:32Z","timestamp":1306914872000},"page":"57-63","source":"Crossref","is-referenced-by-count":7,"title":["Peroxisome Proliferator-Activated Receptor-\u03b3 Is Expressed in Eosinophils in Nasal Polyps"],"prefix":"10.1159","volume":"155","author":[{"given":"Chikara","family":"Asaka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Honda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiko","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Fukui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi","family":"Chihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,6,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2500%2F105065887781693420"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2500%2F108854196778662282"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3109%2F00016489409126104"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02439732"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3109%2F00016488809119457"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0091-6749%2805%2980158-7"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0091-6749%2899%2970118-1"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0385-8146%2899%2900038-3"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1165%2Frcmb.2003-0071OC"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.2008.01677.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.0019-2805.2001.01340.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9440%2810%2963116-1"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2F0092-8674%2895%2990193-0"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.20021384"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2332%2Fallergolint.08-OA-0047"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2004.02.036"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1001%2Farchotol.132.11.1196"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1186%2F1465-9921-6-132"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-2478%2803%2900003-8"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.abb.2003.08.006"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.193.2.255"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1001%2Farchotol.133.7.693"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/327294","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/327294","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:12:03Z","timestamp":1745435523000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000327294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":22,"journal-issue":{"issue":"Suppl. 1","published-online":{"date-parts":[[2011,6,1]]},"published-print":{"date-parts":[[2011,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000327294","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"type":"print","value":"1018-2438"},{"type":"electronic","value":"1423-0097"}],"subject":[],"published":{"date-parts":[[2011]]}}}