{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:39:21Z","timestamp":1791272361908,"version":"4.1.0"},"reference-count":19,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2011]]},"abstract":"<i>Background:<\/i> Neurofibromatosis type 1 is fully penetrant by the age of 8 years, and 3 criteria of diagnosis are dermatological: caf\u00e9-au-lait spots (CLS), intertriginous freckling and neurofibromas (NF). <i>Objectives:<\/i> The aim of our study was to determine the evolving pattern of cutaneous manifestations during adulthood. <i>Methods:<\/i> Phenotypic data of patients seen in our center between March 2003 and December 2009 were studied. Patients were classified in 10-year groups. Following clinical characteristics, the number of CLS and the number of cutaneous and subcutaneous NF were compared according to age. <i>Results:<\/i> 728 subjects, 404 females and 324 males (mean age of 32.4 years, range 6\u201380 years) were studied. Four hundred eighty-nine patients were over 20 years old (67%). The number of CLS (small or large) was significantly decreased with age while the number of cutaneous and subcutaneous NF was strongly increased (p < 0.001). <i>Conclusions:<\/i> The decrease in CLS with age has not been previously reported while an increase in the number of NF is well described during puberty and pregnancy and with age.<\/jats:p>","DOI":"10.1159\/000327379","type":"journal-article","created":{"date-parts":[[2011,5,4]],"date-time":"2011-05-04T05:06:26Z","timestamp":1304485586000},"page":"269-273","source":"Crossref","is-referenced-by-count":74,"title":["Evolving Pattern with Age of Cutaneous Signs in Neurofibromatosis Type 1: A Cross-Sectional Study of 728 Patients"],"prefix":"10.1159","volume":"222","author":[{"given":"T.A.","family":"Duong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Bastuji-Garin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Valeyrie-Allanore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Sbidian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ferkal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Wolkenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,5,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2F111.6.1355"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291096-8628%2819970516%2970%3A2%3C138%3A%3AAID-AJMG7%3E3.0.CO%3B2-U"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2007.07903.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.105.3.608"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.arcped.2006.03.149"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2Fajmg.a.32301"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136%2Fjcp.56.10.758"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1203%2FPDR.0b013e31817445b8"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002%2Fmc.20236"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038%2Fjid.2010.100"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1212%2F01.wnl.0000168830.79997.13"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1001%2Farchdermatol.2009.180"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0749.2004.00206.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00403-006-0644-6"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.2003.05283.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2005.06966.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.1990.tb16121.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1001%2Farchdermatol.2009.169"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038%2Fng2113"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/327379","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/327379","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:12:52Z","timestamp":1745421172000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000327379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":19,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,6,1]]},"published-print":{"date-parts":[[2011,6,29]]}},"URL":"https:\/\/doi.org\/10.1159\/000327379","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}