{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:20:23Z","timestamp":1790983223992,"version":"4.1.0"},"reference-count":22,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2011,4,27]],"date-time":"2011-04-27T00:00:00Z","timestamp":1303862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2011,4,27]],"date-time":"2011-04-27T00:00:00Z","timestamp":1303862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord Extra"],"abstract":"<i>Aim:<\/i> To study long-term effects of dietary patterns on dementia and Alzheimer\u2019s disease (AD). <i>Methods:<\/i> Of 525 subjects randomly selected from population-based cohorts surveyed at midlife, a total of 385 (73%) subjects were re-examined 14 years later in the CAIDE study. A healthy-diet index (range 0\u201317) was constructed including both healthy and unhealthy dietary components. <i>Results:<\/i> Persons with a healthy diet (healthy-diet index >8 points) had a decreased risk of dementia (OR 0.12, 95% CI 0.02\u20130.85) and AD (OR 0.08, 95% CI 0.01\u20130.89) compared with persons with an unhealthy diet (0\u20138 points), adjusting for several possible confounders. <i>Conclusions:<\/i> Healthy diet at midlife is associated with a decreased risk of dementia\/AD in late life. These findings highlight the importance of dietary patterns and may make more effective measures for dementia\/AD prevention or postponement possible.<\/jats:p>","DOI":"10.1159\/000327518","type":"journal-article","created":{"date-parts":[[2011,4,27]],"date-time":"2011-04-27T08:38:09Z","timestamp":1303893489000},"page":"103-112","source":"Crossref","is-referenced-by-count":48,"title":["Midlife Healthy-Diet Index and Late-Life Dementia and Alzheimer\u2019s Disease"],"prefix":"10.1159","volume":"1","author":[{"given":"Marjo H.","family":"Eskelinen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiia","family":"Ngandu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaakko","family":"Tuomilehto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilkka","family":"Soininen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miia","family":"Kivipelto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,4,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159%2F000093478"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093%2Fageing%2Fafn095"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.a1344"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneurol.2010.84"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.20854"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1212%2F01.wnl.0000277320.50685.7c"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.2009.1146"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093%2Fije%2F23.3.495"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2F0895-4356%2888%2990084-4"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2F0022-3956%2875%2990026-6"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.34.7.939"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.1975.00490510088009"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa025039"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.exger.2006.06.002"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS1474-4422%2803%2900438-1"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097%2F00001756-199309000-00013"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.plefa.2007.10.006"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.329.7480.1447"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097%2FHJR.0b013e328308ba61"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1017%2FS1368980008004618"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11910-007-0057-8"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.2337%2Fdc07-2162"}],"container-title":["Dementia and Geriatric Cognitive Disorders Extra"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/327518","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/327518","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:13:38Z","timestamp":1745435618000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000327518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,27]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2011,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000327518","archive":["Portico"],"relation":{},"ISSN":["1664-5464"],"issn-type":[{"value":"1664-5464","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,27]]}}}