{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:51:37Z","timestamp":1761155497324,"version":"3.40.4"},"reference-count":35,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2011,4,27]],"date-time":"2011-04-27T00:00:00Z","timestamp":1303862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2011,4,27]],"date-time":"2011-04-27T00:00:00Z","timestamp":1303862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord Extra"],"abstract":"<jats:p>&lt;i&gt;Objectives:&lt;\/i&gt; To determine if mild cognitive impairment (MCI) represents a continuum of cognitive and functional deficits. &lt;i&gt;Methods:&lt;\/i&gt; Clinical data of 164 subjects with no dementia (ND, n = 52), uncertain dementia (n = 69), and mild probable Alzheimer\u2019s disease (AD, n = 43) were reviewed. Uncertain dementia patients were classified as pre-MCI (n = 11), early amnestic MCI (e-aMCI, n = 15) and late amnestic MCI (l-aMCI, n = 15). Cognitive assessments [Chinese Mini-Mental State Examination (CMMSE) and a validated neuropsychological battery], functional assessments (Lawton\u2019s scale for instrumental activities of daily living) and neuroimaging (ischemic lesions and medial temporal lobe atrophy) were reviewed. &lt;i&gt;Results:&lt;\/i&gt; ND, aMCI and mild AD subjects demonstrated a significant trend for worsening performance for all cognitive and functional measures (ANOVA, p &lt; 0.05). Pre-MCI subjects performed significantly better than aMCI subjects in all verbal memory domains (p &lt; 0.001), while l-aMCI had worse functional performance (p = 0.007), a trend towards greater depressive symptoms (p = 0.05) and higher medial temporal lobe atrophy scores (p = 0.06). l-aMCI subjects were more likely than either pre-MCI or e-aMCI to progress to dementia over a mean follow-up period of 2.5 years (46.7 vs. 9.1 and 20.0%, respectively). &lt;i&gt;Conclusions:&lt;\/i&gt; Clinical delineation of aMCI allows the differentiation of those likely to progress for better correlation to biomarker development.<\/jats:p>","DOI":"10.1159\/000327519","type":"journal-article","created":{"date-parts":[[2011,4,27]],"date-time":"2011-04-27T08:38:09Z","timestamp":1303893489000},"page":"113-123","source":"Crossref","is-referenced-by-count":11,"title":["Amnestic Mild Cognitive Impairment and Early Alzheimer\u2019s Disease in an Asian Memory Clinic \u2013 Evidence for a Clinical 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