{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:07:29Z","timestamp":1761059249039,"version":"3.40.4"},"reference-count":9,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2011,10,5]],"date-time":"2011-10-05T00:00:00Z","timestamp":1317772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,10,5]],"date-time":"2011-10-05T00:00:00Z","timestamp":1317772800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Wheat is an important food allergen associated with severe allergic reactions, including wheat-dependent exercise-induced anaphylaxis (WDEIA) and wheat-induced anaphylaxis (WIA). To diagnose WDEIA, an exercise challenge test following wheat ingestion is performed, which is time-consuming and unsafe. The compound \u03c9-5 gliadin has been identified as a major allergen for WDEIA and WIA. We evaluated the diagnostic value of serum immunoglobulin E (IgE) ratios of \u03c9-5 gliadin to wheat in adult patients with WDEIA or WIA. &lt;i&gt;Methods:&lt;\/i&gt; In total, 27 patients were enrolled and classified into 2 groups according to the severity of their allergic reactions to wheat. Serum IgE, specific to wheat and \u03c9-5 gliadin, was measured using the ImmunoCAP system. To evaluate the diagnostic value, receiver operator characteristic curves were produced. &lt;i&gt;Results:&lt;\/i&gt; Group 1 included 17 patients with a history of anaphylaxis and group 2 included 10 patients having urticaria or atopic dermatitis. Serum IgE specific to wheat was increased in 47% of group 1 and 100% of group 2. However, all patients in group 1 had high serum IgE specific to \u03c9-5 gliadin, whereas only 20% of group 2 showed increased levels. To identify a better diagnostic value, the log-transformed IgE ratio of \u03c9-5 gliadin to wheat was calculated, with the cutoff value at 0.3. Based on these criteria, we found 100% sensitivity and specificity. &lt;i&gt;Conclusions:&lt;\/i&gt; This study confirms that the serum IgE ratio of \u03c9-5 gliadin to wheat may be a useful marker for the diagnosis of WDEIA and WIA.<\/jats:p>","DOI":"10.1159\/000327549","type":"journal-article","created":{"date-parts":[[2011,10,5]],"date-time":"2011-10-05T07:05:15Z","timestamp":1317798315000},"page":"147-150","source":"Crossref","is-referenced-by-count":29,"title":["Diagnostic Value of the Serum-Specific IgE Ratio of \u03c9-5 Gliadin to Wheat in Adult Patients with Wheat-Induced Anaphylaxis"],"prefix":"10.1159","volume":"157","author":[{"given":"Han-Jung","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo-Hee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong-Eun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun-Jung","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gil-Soon","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Min","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hae-Sim","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,10,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2FACI.0b013e32832aa5bc"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.2007.01504.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2001.118602"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159%2F000176309"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1398-9995.2003.02170.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2230.2009.03709.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS1081-1206%2810%2961107-6"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1399-3038.2005.00263.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2001.114708"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/327549","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/327549","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:13:48Z","timestamp":1745435628000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000327549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,5]]},"references-count":9,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,2,1]]},"published-print":{"date-parts":[[2012,2,2]]}},"URL":"https:\/\/doi.org\/10.1159\/000327549","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"type":"print","value":"1018-2438"},{"type":"electronic","value":"1423-0097"}],"subject":[],"published":{"date-parts":[[2011,10,5]]}}}