{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T06:48:08Z","timestamp":1772174888552,"version":"3.50.1"},"reference-count":61,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2011,10,6]],"date-time":"2011-10-06T00:00:00Z","timestamp":1317859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,10,6]],"date-time":"2011-10-06T00:00:00Z","timestamp":1317859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; S\u00e9zary syndrome (SS) is the aggressive leukemic form of cutaneous T cell lymphoma characterized by erythroderma, the presence of a malignant circulating T memory cells with skin homing potential, and the ability to produce a variety of Th2 soluble factors, such as IL-4 and IL-5. We measured total and specific IgE in SS patients as a further parameter of a Th2-skewed immune system, and studied their clinical impact. &lt;i&gt;Methods:&lt;\/i&gt; Specific IgE production in a cohort of 55 SS patients was evaluated by the molecule-based ISAC microarray system. We then evaluated survival times and the hazard ratios in this cohort by Kaplan-Meier and Cox methods. &lt;i&gt;Results:&lt;\/i&gt; Twenty-four (43.6%) SS patients had specific IgE to both environmental and food allergens. For survival analysis, patients found positive to at least one allergen were defined as IgE+. By comparing IgE+ versus IgE\u2013 we found a significant difference in the median survival times, 2.9 versus 8.9 years (p &lt; 0.001). Conversely, no survival difference could be observed when total IgE levels were considered. IgE+ patients had higher levels of CD60+CD49\u2013CD4+ T cells, which also represent another worse prognostic index recently identified. &lt;i&gt;Conclusion:&lt;\/i&gt; SS patients had specific IgE to both environmental and food allergens. IgE+ SS patients had a significant lower survival rate. High levels of CD60\u2013CD49+CD4+ T cells associated with an IgE\u2013 phenotype allow the identification of a restricted group of long survivor SS patients. Therefore, specific measurement of IgE seems to be useful in discriminating survival.<\/jats:p>","DOI":"10.1159\/000327553","type":"journal-article","created":{"date-parts":[[2011,10,6]],"date-time":"2011-10-06T06:48:05Z","timestamp":1317883685000},"page":"159-167","source":"Crossref","is-referenced-by-count":14,"title":["Specific IgE toward Allergenic Molecules Is a New Prognostic Marker in Patients with S\u00e9zary Syndrome"],"prefix":"10.1159","volume":"157","author":[{"given":"Enrico","family":"Scala","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damiano","family":"Abeni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Palazzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Liso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debora","family":"Pomponi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Lombardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Cristina","family":"Picchio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Grazia","family":"Narducci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giandomenico","family":"Russo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriano","family":"Mari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,10,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2006-10-054601"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2808%2960420-1"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMra032810"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1182%2Fasheducation-2009.1.523"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2009-03-209262"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.2003.05224.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2249.1998.00599.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2F1523-1747.ep12388985"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2F1523-1747.ep12611877"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2807%2980011-9"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.112.10.1391"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.140.9.1057"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2F0091-6749%2893%2990046-I"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-4632.2010.04228.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.141.9.1123"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.120.1.83"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.1999.02775.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159%2F000182251"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2005.07077.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2003.05551.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1159%2F000108133"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.2002.04872.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2000.105528"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI116711"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016%2FS0091-6749%2899%2970390-8"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2000.105524"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2222.1998.00397.x"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2222.2000.00848.x"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2008.08612.x"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.1995.tb02485.x"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2222.2010.03470.x"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ymeth.2003.08.018"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2222.2003.01550.x"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.2307%2F2281868"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2005.06755.x"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2005-04-1492"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1747.2002.18194.x"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1023%2FB%3ACACO.0000027506.55846.5d"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.1995.tb01212.x"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1186%2F1471-2458-4-51"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1093%2Faje%2Fkwg020"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.thj.6200154"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1186%2F1710-1492-5-12"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00403-006-0705-x"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-3083.2008.02169.x"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1006%2Fcimm.1998.1336"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1111%2F1523-1747.ep12472333"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1747.1999.00718.x"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1309%2FU1Y6-J4AG-5M4M-7AYV"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.180.6.2125"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004030050075"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.1993.tb00257.x"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1016%2FS0065-2776%2808%2960534-9"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.181.2.747"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2249.2003.02203.x"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2249.2000.01270.x"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.0022-202X.2004.23586.x"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1159%2F000024320"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1002%2Fijc.21788"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1096%2Ffj.02-1070com"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1016%2FS1521-6616%2803%2900167-0"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/327553","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/327553","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:13:49Z","timestamp":1745435629000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000327553"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,6]]},"references-count":61,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,2,1]]},"published-print":{"date-parts":[[2012,2,2]]}},"URL":"https:\/\/doi.org\/10.1159\/000327553","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,6]]}}}