{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T21:38:54Z","timestamp":1772833134651,"version":"3.50.1"},"reference-count":18,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis"],"published-print":{"date-parts":[[2011]]},"abstract":"<i>Objective:<\/i> Hepatocellular carcinoma (HCC) is one of the most common cancers and is mainly caused by viral infections including hepatitis B virus (HBV). Recently, the decreased expression level of the <i>transforming growth factor, beta receptor III<\/i> (<i>TGFBR3<\/i>) gene, has been implicated in HCC and other human cancers. This study investigated whether <i>TGFBR3<\/i> polymorphisms might be associated with HBV clearance and HCC occurrence. <i>Methods:<\/i> This study identified 27 single nucleotide polymorphisms (SNPs) in the exon, promoter, and exon-intron boundary regions of <i>TGFBR3<\/i> by resequencing in 24 individuals. Then, 9 SNPs in the promoter and exons of the gene were genotyped from 1,065 Koreans composed of 637 chronic carriers (CC) and 428 spontaneously recovered (SR) subjects. <i>Results:<\/i> Two SNPs, <i>rs1805113<\/i> (Phe676Phe) in exon 13 and <i>rs1805117<\/i> in 3\u2032-UTR (p = 0.009 and p = 0.008, respectively) were significantly associated with HBV clearance. In addition, Cox relative hazards analyses revealed that haplotype<i> BL2_ht2 <\/i>showed a significant association with the age of HCC occurrence among chronic HBV patients (relative hazard = 1.38; p = 0.007). <i>Conclusion:<\/i> Our findings suggest that <i>TGFBR3<\/i> polymorphisms and its haplotypes might be associated with HBV clearance and age of HCC occurrence.<\/jats:p>","DOI":"10.1159\/000327559","type":"journal-article","created":{"date-parts":[[2011,8,9]],"date-time":"2011-08-09T14:06:30Z","timestamp":1312898790000},"page":"278-283","source":"Crossref","is-referenced-by-count":12,"title":["<i>TGFBR3<\/i> Polymorphisms and Its Haplotypes Associated with Chronic Hepatitis B Virus Infection and Age of Hepatocellular Carcinoma Occurrence"],"prefix":"10.1159","volume":"29","author":[{"given":"Jeong-Hyun","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su Jong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung-Lae","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Sub","family":"Cheong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charisse Flerida A.","family":"Pasaje","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joon Seol","family":"Bae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo-Suk","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyoung Doo","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon Jun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,8,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2893.2009.01117.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS1470-2045%2808%2970285-7"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2F0166-0934%2887%2990070-X"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0166-3542%2801%2900175-9"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.onc.1206835"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI29293"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1158%2F0008-5472.CAN-06-3117"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1165%2Frcmb.2008-0427OC"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002%2Fjmv.10506"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2Fhep.1840030302"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.294.13.1634"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0092-8674%2800%2980127-0"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0960-9822%2807%2900533-7"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.2007.01593.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2500%2Faap.2008.29.3091"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1146%2Fannurev.iy.07.040189.001045"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1534%2Fgenetics.104.026351"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0404957101"}],"container-title":["Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/327559","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/327559","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:13:51Z","timestamp":1745435631000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000327559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":18,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,8,1]]},"published-print":{"date-parts":[[2011,8,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000327559","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5121859","asserted-by":"subject"}]},"ISSN":["0257-2753","1421-9875"],"issn-type":[{"value":"0257-2753","type":"print"},{"value":"1421-9875","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}