{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T07:46:31Z","timestamp":1759563991983,"version":"3.40.4"},"reference-count":26,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychobiology"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Psychostimulant-mediated synaptic plasticity in the hippocampus and nucleus accumbens is one of the pathological features of addiction, a disease of learning and memory. Dynamic palmitoylation of PSD-95 modulates synaptic plasticity, but its role in addiction is not fully understood. Using a morphine-conditioned place preference (CPP) rat model and Acyl-biotin exchange (ABE) labeling we found a correlation between CPP and levels of palmitoylated PSD-95 in the hippocampus and nucleus accumbens. Rats that developed significant CPP had higher levels of palmitoylation of PSD-95 in the hippocampus and nucleus accumbens. Furthermore, palmitoylation of PSD-95 was significantly decreased in the hippocampus but increased in the nucleus accumbens during the beginning of withdrawal. With long-term withdrawal, palmitoylated PSD-95 in these regions recovered, while CPP waned and physical signs gradually disappeared. However, morphine reinjection restored strong CPP without producing any significant changes in palmitoylation of PSD-95. Our findings suggest that CPP is correlated with the dynamics of PSD-95 palmitoylation in rat hippocampus and nucleus accumbens, and could be one of the mechanisms for morphine-dependent synaptic plasticity.<\/jats:p>","DOI":"10.1159\/000327603","type":"journal-article","created":{"date-parts":[[2011,9,8]],"date-time":"2011-09-08T07:38:02Z","timestamp":1315467482000},"page":"211-218","source":"Crossref","is-referenced-by-count":8,"title":["Conditioned Place Preference Associated with Level of Palmitoylation of PSD-95 in Rat Hippocampus and Nucleus Accumbens"],"prefix":"10.1159","volume":"64","author":[{"given":"Xiaojie","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuebing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daijun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haidan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,9,9]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1146%2Fannurev.neuro.29.051605.113009"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1038%2F361031a0"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1016%2Fj.neuroscience.2006.10.018"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1016%2FS0896-6273%2804%2900048-0"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1126%2Fscience.1075333"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1038%2F24790"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1523%2FJNEUROSCI.3159-04.2004"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1007%2FPL00000637"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1126%2Fscience.287.5461.2262"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1016%2Fj.conb.2005.08.001"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.1083%2Fjcb.200610151"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.1016%2Fj.neuron.2004.12.005"},{"doi-asserted-by":"publisher","key":"ref13","DOI":"10.1159%2F000105517"},{"doi-asserted-by":"publisher","key":"ref14","DOI":"10.1016%2Fj.neuron.2004.11.027"},{"doi-asserted-by":"publisher","key":"ref15","DOI":"10.1038%2Fng1375"},{"doi-asserted-by":"publisher","key":"ref16","DOI":"10.1038%2Fnn.2204"},{"doi-asserted-by":"publisher","key":"ref17","DOI":"10.1086%2F513609"},{"doi-asserted-by":"publisher","key":"ref18","DOI":"10.1002%2Felps.200700791"},{"doi-asserted-by":"publisher","key":"ref19","DOI":"10.3389%2Fneuro.02.004.2008"},{"doi-asserted-by":"publisher","key":"ref20","DOI":"10.1046%2Fj.1471-4159.2004.02364.x"},{"doi-asserted-by":"publisher","key":"ref21","DOI":"10.1111%2Fj.1460-9568.2006.05247.x"},{"doi-asserted-by":"publisher","key":"ref22","DOI":"10.1038%2Fnprot.2007.225"},{"doi-asserted-by":"publisher","key":"ref23","DOI":"10.1016%2Fj.molbrainres.2005.02.021"},{"doi-asserted-by":"publisher","key":"ref24","DOI":"10.1016%2Fj.tins.2004.09.002"},{"doi-asserted-by":"publisher","key":"ref25","DOI":"10.1016%2Fj.neuron.2010.06.004"},{"doi-asserted-by":"publisher","key":"ref26","DOI":"10.1016%2FS0092-8674%2802%2900683-9"}],"container-title":["Neuropsychobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/327603","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/327603","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:14:30Z","timestamp":1745435670000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000327603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":26,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2011,9,1]]},"published-print":{"date-parts":[[2011,9,9]]}},"URL":"https:\/\/doi.org\/10.1159\/000327603","archive":["Portico"],"relation":{},"ISSN":["0302-282X","1423-0224"],"issn-type":[{"type":"print","value":"0302-282X"},{"type":"electronic","value":"1423-0224"}],"subject":[],"published":{"date-parts":[[2011]]}}}