{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:32:13Z","timestamp":1783488733448,"version":"3.55.0"},"reference-count":86,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Following the introduction of life-saving glucocorticoid replacement 60 years ago, congenital adrenal hyperplasia (CAH) has evolved from being perceived as a paediatric disorder to being recognized as a lifelong, chronic condition affecting patients of all age groups. Increasing evidence suggests that patients with CAH have an increased risk to develop health problems during adult life, with signs and symptoms of forerunner conditions of adult disease already emerging during the time of paediatric care. Transition of paediatric CAH patients to medical care in the adult setting is an important step to ensure optimal lifelong treatment, aiming to achieve good health and normal life expectancy and quality of life. Thus, primary and secondary prevention of health problems has to become a task of increasing importance for those involved in the care of CAH patients throughout their life.<\/jats:p>","DOI":"10.1159\/000327794","type":"journal-article","created":{"date-parts":[[2011,5,18]],"date-time":"2011-05-18T06:33:54Z","timestamp":1305700434000},"page":"73-85","source":"Crossref","is-referenced-by-count":82,"title":["Health Problems in Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency"],"prefix":"10.1159","volume":"76","author":[{"given":"Nicole","family":"Reisch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiebke","family":"Arlt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Krone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,5,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210%2Fer.21.3.245"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2805%2966736-0"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2265.2006.02740.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159%2F000110615"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2006-0964"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000065490"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2009-2631"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2002-030011"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2009-0942"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2006-2109"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2005-1701"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2803%2913492-7"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159%2F000065492"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2008-0519"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1530%2FEJE-08-0874"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2265.2006.02544.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2009-0630"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2265.2009.03636.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1203%2FPDR.0b013e3181b1bbec"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.beem.2008.10.010"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.80.7.2238"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2F8756-3282%2896%2900003-8"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2265.1996.8620871.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2265.1996.00851.x"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1530%2Feje.0.1430667"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1159%2F000053253"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2002-021074"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1159%2F000075588"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2005-0745"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2007-0744"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2010-0917"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2005-2823"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1159%2F000098017"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1530%2FEJE-07-0887"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2005-1005"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2006-1069"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.78.3.261"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2265.2009.03587.x"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2006-1350"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.87.5.2114"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1159%2F000086363"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1530%2FEJE-08-0770"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2265.2003.01757.x"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1515%2FJPEM.2004.17.8.1089"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1159%2F000308891"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1053%2Fmeta.2000.6261"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2006-1711"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1507%2Fendocrj.51.601"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1159%2F000313368"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2007-1001755"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1530%2FEJE-09-0523"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM198701223160402"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2265.2001.01359.x"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.fertnstert.2003.10.024"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2265.2009.03563.x"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2265.1995.tb02034.x"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1530%2Feje.1.02096"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2006-0062"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2009-1383"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10508-007-9265-1"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.86.7.3070"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.86.12.5721"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2008-1414"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2007-0383"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1530%2FEJE-07-0201"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00330-004-2329-x"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1515%2FJPEM.2006.19.2.177"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.beem.2008.09.007"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2009-1929"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2006-1311"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2007-0556"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02276713"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1080%2F080352500750028807"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2009-0636"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1530%2FEJE-10-0284"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2265.2010.03920.x"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.82.12.3926"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.100.4.671"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00774-003-0434-6"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.75.6.1421"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1515%2FJPEM.2006.19.5.705"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1007%2Fs12020-006-0005-4"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1651-2227.2009.01231.x"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumrep%2Fden118"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1530%2Feje.1.02294"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM197812212992505"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/327794","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/327794","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:15:40Z","timestamp":1745435740000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000327794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":86,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,8,1]]},"published-print":{"date-parts":[[2011,8,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000327794","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}