{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:42:17Z","timestamp":1791477737447,"version":"4.3.4"},"reference-count":39,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurodegener Dis"],"published-print":{"date-parts":[[2011]]},"abstract":"<i>Background:<\/i> Because amyotrophic lateral sclerosis (ALS) is a progressive inflammatory disease, treatment of the pulmonary system plays a key role in ALS patients\u2019 care. Previous studies have mainly examined the pathological mechanism of ALS in the central nervous system; however, there has been relatively little research regarding the pulmonary system in ALS animal models. In inflammatory diseases, including asthma and arthritis, electroacupuncture (EA) is commonly used for its anti-inflammatory effects. The goal of this study was to determine whether EA treatment affects inflammation in the pulmonary system in an ALS animal model. <i>Methods:<\/i> EA treatment at ST36 (Zusanli) acupoint was performed with 14-week-old hSOD1<sup>G93A<\/sup> transgenic mice. Immunohistochemical analysis was performed using anti-ionized calcium binding adaptor molecule 1 (Iba-1) and anti-tumor necrosis factor alpha (TNF-\u03b1) antibodies. To investigate the expression level of inflammatory proteins, Western blot analyses were performed using anti-Iba-1, anti-TNF-\u03b1, anti-nuclear factor kappa B (NF-\u0138B), and anti-interleukin 6 (IL-6) antibodies. The activation of Ser435-phospho-specific RAC-alpha serine\/threonine-protein kinase 1 (pAKT) and the increase of phosphorylated extracellular-signal-regulated kinases (pERK) protein in lung tissues of EA-treated and untreated hSOD1<sup>G93A<\/sup> mice were also evaluated by Western blot. <i>Results:<\/i> EA treatment decreased the expression of the proinflammatory proteins such as TNF-\u03b1 and IL-6, pNF-\u0138B, and Iba-1 and increased the level of activated pAKT and pERK compared to control hSOD1<sup>G93A<\/sup> mice. <i>Conclusions:<\/i> Our findings suggest that EA could be an effective anti-inflammatory treatment for the respiratory impairment that occurs in ALS animal models.<\/jats:p>","DOI":"10.1159\/000327911","type":"journal-article","created":{"date-parts":[[2011,8,18]],"date-time":"2011-08-18T06:46:48Z","timestamp":1313650008000},"page":"504-514","source":"Crossref","is-referenced-by-count":29,"title":["Anti-Inflammatory Effects of Electroacupuncture in the Respiratory System of a Symptomatic Amyotrophic Lateral Sclerosis Animal Model"],"prefix":"10.1159","volume":"8","author":[{"given":"Jing Hua","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Jin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung Gi","family":"Baek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seon Hwy","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Min","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun-Mi","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,8,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neuron.2006.09.018"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.21543"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jneuroim.2010.04.005"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038%2F362059a0"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.410430319"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.8209258"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.expneurol.2010.03.030"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11481-009-9171-5"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186%2F1476-9255-7-3"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186%2F1750-1172-4-3"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097%2FWNR.0b013e328331e8fa"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002%2Fglia.20919"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0911405106"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1371%2Fjournal.pone.0002740"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.expneurol.2007.05.007"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jneumeth.2010.07.016"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002%2Fmds.23105"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159%2F000107285"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1089%2Facm.2005.11.135"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002%2Fpmic.200700955"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1051%2Fvetres%2F2009050"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.tibs.2004.11.009"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neuropharm.2010.10.016"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.2174%2F1568009043333032"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.brainres.2010.08.002"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2FS0169-328X%2898%2900040-0"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1212%2F01.wnl.0000188907.97339.76"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016%2FS1359-6101%2899%2900008-8"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1021%2Fes103031a"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.molimm.2010.10.001"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016%2FS0074-7742%2804%2959008-6"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1128%2FMMBR.68.2.320-344.2004"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.1067833"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.cdd.4401662"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.it.2008.01.010"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.tins.2005.09.001"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.1110647"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00415-010-5825-8"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI30555"}],"container-title":["Neurodegenerative 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