{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:46:10Z","timestamp":1757706370824,"version":"3.40.4"},"reference-count":14,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2011]]},"abstract":"<i>Objectives:<\/i> The aim of this study was to estimate the survival impact of adjuvant paclitaxel and carboplatin (TC) compared to cisplatin (CDDP)-based chemotherapies for early-stage ovarian clear-cell carcinoma (CCC). <i>Methods:<\/i> Clinicopathologic information on 99 stage I\u2013II CCC patients was obtained between 1987 and 2005. All patients underwent complete surgical staging including systemic lymphadenectomy, followed by TC or various CDDP-based regimens. In the present study, only CCC patients with no residual tumor were enrolled. <i>Results:<\/i> The median age was 53 years and ranged from 30 to 69 years. Fifty-three (53.5%) patients received TC and 46 (46.5%) patients underwent various CDDP-based chemotherapies after initial surgery. Five-year progression-free survival (PFS) rates of TC and various CDDP groups were 66.5 and 75.8%, respectively (n.s., p = 0.933). In addition, 5-year overall survival (OS) rates of TC and various CDDP groups were 82.4 and 82.3%, respectively (n.s., p = 0.583). In multivariate analyses of OS and PFS, the regimen of chemotherapywas not a significant prognostic factor (OS, p = 0.502; PFS, p = 0.977. <i>Conclusions:<\/i> In our current examination of the long-term survival of early-stage CCC patients, we did not identify a superiority of TC over various CDDP-based regimens as frontline adjuvant chemotherapy.<\/jats:p>","DOI":"10.1159\/000327924","type":"journal-article","created":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T14:27:13Z","timestamp":1320157633000},"page":"252-256","source":"Crossref","is-referenced-by-count":8,"title":["Survival Impact of Adjuvant Paclitaxel and Carboplatin for Early-Stage Ovarian Clear-Cell Carcinoma with Complete Surgical Staging"],"prefix":"10.1159","volume":"72","author":[{"given":"Hiroaki","family":"Kajiyama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyosumi","family":"Shibata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiro","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Ino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiyasu","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuro","family":"Nagasaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Nawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumitaka","family":"Kikkawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,10,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199601043340101"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2003.07.013"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1006%2Fgyno.1998.5145"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%2820000601%2988%3A11%3C2584%3A%3AAID-CNCR22%3E3.0.CO%3B2-5"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2F0090-8258%2889%2990637-9"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1006%2Fgyno.1996.0065"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%28197004%2925%3A4%3C762%3A%3AAID-CNCR2820250404%3E3.0.CO%3B2-3"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ygyno.2004.04.004"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0142%2819961115%2978%3A10%3C2157%3A%3AAID-CNCR17%3E3.0.CO%3B2-Y"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3835%2800%2900605-4"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1006%2Fgyno.1998.5071"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1525-1438.2006.00289.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ygyno.2005.03.009"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10147-007-0670-1"}],"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/327924","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/327924","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/327924","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:17:09Z","timestamp":1745435829000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000327924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":14,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2011,12,1]]},"published-print":{"date-parts":[[2011,12,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000327924","archive":["Portico"],"relation":{},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"type":"print","value":"0378-7346"},{"type":"electronic","value":"1423-002X"}],"subject":[],"published":{"date-parts":[[2011]]}}}