{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:21:12Z","timestamp":1772137272730,"version":"3.50.1"},"reference-count":23,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2011]]},"abstract":"<i>Introduction:<\/i> To evaluate if an inflammatory pattern at primary biopsy is associated with a lower risk for cancer in men submitted to repeated saturation prostate biopsy (SPBx). <i>Methods:<\/i> From January 2005 to January 2010, 320 patients, after a negative primary extended biopsy (median 18 cores), underwent SPBx by transperineal approach performing 27 cores (median). 210 (65.6%) patients had a normal parenchyma and 110 had an inflammatory pattern (34.4%) at primary biopsy (none of them complained of symptoms suggesting a diagnosis of acute prostatitis at the time of biopsy). Moreover, median prostate-specific antigen and abnormal digital rectal examination was equal to 7.3 ng\/ml and 3.6% versus 8.2 ng\/ml and 3.8%, respectively. <i>Results:<\/i> Prostate cancer (PCa) was found in 66 (20.5%) of 320 patients. Of these, 42 (63.6%) and 24 (36.4%; p = 0.007) had a histological diagnosis of chronic prostatitis and normal parenchyma at primary biopsy, respectively. <i>Conclusions:<\/i> An inflammatory pattern at primary biopsy is not associated with a decrease in PCa incidence at repeated SPBx; therefore, only an accurate clinical evaluation including more parameters (i.e. urinary PCA3) could hopefully select men who need to undergo rebiopsy in the presence of persistent suspicion of cancer.<\/jats:p>","DOI":"10.1159\/000328043","type":"journal-article","created":{"date-parts":[[2011,9,12]],"date-time":"2011-09-12T11:29:11Z","timestamp":1315826951000},"page":"171-174","source":"Crossref","is-referenced-by-count":13,"title":["Does an Inflammatory Pattern at Primary Biopsy Suggest a Lower Risk for Prostate Cancer at Repeated Saturation Prostate Biopsy"],"prefix":"10.1159","volume":"87","author":[{"given":"Pietro","family":"Pepe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Aragona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,7,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159%2F000071839"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1439-0272.2007.00820.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.juro.2009.11.044"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.pcan.4500996"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11255-009-9598-x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-5347%2805%2963959-6"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000112612"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.pcan.4500885"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.282.3.236"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186%2F1471-2407-10-326"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ju.0000142058.99614.ff"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038%2Fnrc2090"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1742-1241.2006.00905.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002%2Fpros.20992"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.eururo.2004.11.007"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.urology.2007.07.068"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159%2F000052500"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.urology.2007.06.1102"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ju.0000162017.24965.2b"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1159%2F000089730"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1590%2FS1677-55382009000500006"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1159%2F000209355"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.purol.2010.01.001"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/328043","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/328043","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:18:43Z","timestamp":1745435923000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000328043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":23,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,9,1]]},"published-print":{"date-parts":[[2011,9,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000328043","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}