{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:51:53Z","timestamp":1768351913509,"version":"3.49.0"},"reference-count":28,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebrovasc Dis"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; A major concern with carotid artery stenting (CAS) is the potential for cerebral embolism. The purpose of this study was to determine whether virtual histology intravascular ultrasound (VH-IVUS) can predict the risk of a silent ischemic lesion after CAS. &lt;i&gt;Methods:&lt;\/i&gt; We performed CAS in 45 patients with carotid stenosis. Before CAS, we assessed plaque characteristics by VH-IVUS. We also performed diffusion-weighted magnetic resonance imaging of the brain before and after CAS to detect newly appearing ipsilateral silent ischemic lesions (NISIL). &lt;i&gt;Results:&lt;\/i&gt; In the patient group that was positive for NISIL (P group: n = 18), the relative fibrofatty (FF) area identified by VH-IVUS in 5 cross-sections including the most stenotic lesion was significantly larger than that in areas of the NISIL-negative group (N group: n = 27; 32.7 \u00b1 13.2 and 18.3 \u00b1 9.8%, respectively; p &lt; 0.001). The relative fibrous area was significantly lower in the P group than in the N group (59.2 \u00b1 9.5 and 74.6 \u00b1 9.1%, respectively; p &lt; 0.001). There were no differences in the relative dense calcium and necrotic core areas between the P and N groups. From the analysis of receiver operating characteristic curves, most reliable cutoff values for predicting NISIL were a relative FF area of 30% in the most stenotic lesion. In multivariate logistic regression analysis, the relative FF area was an independent predictor of NISIL (p = 0.005). &lt;i&gt;Conclusions:&lt;\/i&gt; Quantitative tissue characterization of atherosclerotic lesions of carotid arteries using VH-IVUS was useful to predict NISIL after CAS. However, the positive predictive value determined by VH-IVUS was not superior to that determined by a noninvasive method.<\/jats:p>","DOI":"10.1159\/000328231","type":"journal-article","created":{"date-parts":[[2011,6,28]],"date-time":"2011-06-28T11:36:02Z","timestamp":1309260962000},"page":"106-113","source":"Crossref","is-referenced-by-count":23,"title":["Prediction of Silent Ischemic Lesions after Carotid Artery Stenting Using Virtual Histology Intravascular Ultrasound"],"prefix":"10.1159","volume":"32","author":[{"given":"Kiyofumi","family":"Yamada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Kawasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukiko","family":"Enomoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyohei","family":"Takano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiko","family":"Asano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Minatoguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Iwama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,6,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa040127"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa0912321"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1583%2F1074-6218%281996%29003%3C0203%3AIUAICI%3E2.0.CO%3B2"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jacc.2004.10.080"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000097067.96619.1F"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000017200.47342.10"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000035654.18341.5E"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jacc.2006.02.044"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0741-5214%2898%2970321-0"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000138103.91187.E3"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199108153250701"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2801%2901175-5"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.19.5.604"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.28.2.307"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000236492.86303.85"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2803%2900901-X"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jvs.2005.05.065"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1583%2F03-1128.1"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159%2F000297962"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1093%2Feurheartj%2Fehn248"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.atherosclerosis.2009.06.024"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3174%2Fajnr.A1015"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1227%2F01.NEU.0000346271.31050.AF"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.104.483024"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1253%2Fcircj.CJ-10-0547"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jvs.2010.05.101"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.292.15.1845"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1002%2Fccd.10645"}],"container-title":["Cerebrovascular 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