{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T15:35:33Z","timestamp":1788622533306,"version":"build-2803163510"},"reference-count":20,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroepidemiology"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; White matter hyperintensities (WMHs) are a risk factor for stroke. Their etiology is considered to be cerebral microvascular abnormality. However, the association between WMHs and arteriosclerosis is not yet clear. The aim of this hospital-based cohort study was to identify the arteriosclerotic characteristics associated with WMHs. &lt;i&gt;Methods:&lt;\/i&gt; We cross-sectionally included 240 consecutive patients with no history of stroke. We measured the brachial-ankle pulse wave velocity (baPWV), ankle brachial pressure index, and intima-media thickness of the common carotid artery, and we performed magnetic resonance brain imaging. WMHs were defined as periventricular hyperintensity (Fazekas grade \u22673) and\/or separate deep white matter hyperintense signals (Fazekas grade \u22672). We determined the prevalence of WMHs, silent brain infarction (SBI), hypertension, hypercholesterolemia, diabetes mellitus, ischemic heart disease, and smoking. We compared 2 groups of patients, defined by the presence or absence of WMHs, using multiple logistic regression analyses. &lt;i&gt;Results:&lt;\/i&gt; In multivariable analysis, SBI (OR 3.38; 95% CI 1.52\u20137.72), hypertension (OR 2.23; 95% CI 1.03\u20135.15), female sex (OR 1.95; 95% CI 1.03\u20133.76), baPWV (OR 1.12; 95% CI 1.02\u20131.23), and age (OR 1.09; 95% CI 1.04\u20131.14) were independently associated with WMHs. &lt;i&gt;Conclusions:&lt;\/i&gt; An increased baPWV is associated with WMHs. Management of increased baPWV may help to prevent the progression of WMHs and stroke.<\/jats:p>","DOI":"10.1159\/000328260","type":"journal-article","created":{"date-parts":[[2011,6,15]],"date-time":"2011-06-15T15:11:53Z","timestamp":1308150713000},"page":"252-257","source":"Crossref","is-referenced-by-count":46,"title":["Increased Brachial-Ankle Pulse Wave Velocity Is Independently Associated with White Matter Hyperintensities"],"prefix":"10.1159","volume":"36","author":[{"given":"Naoki","family":"Saji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshitaka","family":"Kawarai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Tadano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Kita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Yokono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,6,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159%2F000306058"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159%2F000255970"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000068408.82115.D2"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jstrokecerebrovasdis.2009.12.005"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1291%2Fhypres.28.797"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000093235"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2F0140-6736%2893%2991144-B"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.c3666"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jstrokecerebrovasdis.2005.11.001"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ijcard.2009.02.005"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1291%2Fhypres.31.75"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clineuro.2008.03.009"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159%2F000166837"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159%2F000313443"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159%2F000260071"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159%2F000209236"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0021-9150%2802%2900332-5"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1161%2F01.ATV.0000160548.78317.29"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1001%2Farchinte.163.16.1939"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.43.9.1683"}],"container-title":["Neuroepidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/328260","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/328260","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:19:28Z","timestamp":1745435968000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000328260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":20,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2011,7,1]]},"published-print":{"date-parts":[[2011,7,27]]}},"URL":"https:\/\/doi.org\/10.1159\/000328260","archive":["Portico"],"relation":{},"ISSN":["0251-5350","1423-0208"],"issn-type":[{"value":"0251-5350","type":"print"},{"value":"1423-0208","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}