{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T15:02:51Z","timestamp":1748444571060,"version":"3.40.4"},"reference-count":39,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aim:&lt;\/i&gt; We previously reported the beneficial effects of a combination therapy of interferon (IFN)-\u03b1\/5-fluorouracil (FU) for advanced hepatocellular carcinoma (HCC) with tumor thrombi in the major portal branches. This report describes the results of longer follow-up and includes more than twice the number of patients relative to the previous report; it also evaluates the clinical predictor on the response to the combination therapy and long-term survival. &lt;i&gt;Methods:&lt;\/i&gt; The study subjects were 102 patients with advanced HCC and tumor thrombi in the major branches of the portal vein (Vp3 or 4). They were treated with at least 2 courses of IFN-\u03b1\/5-FU. &lt;i&gt;Results:&lt;\/i&gt; No major treatment-related complications were noted. In the 102 patients, 40 (39.2%) showed objective response [11 (10.8%) showed complete response, 29 (28.4%) partial response], 8 (7.9%) showed no response and 54 (52.9%) showed progressive disease. &lt;i&gt;Conclusion:&lt;\/i&gt; IFN-\u03b1\/5-FU combination therapy is a promising modality for advanced HCC with tumor thrombi in the major portal branches.<\/jats:p>","DOI":"10.1159\/000328281","type":"journal-article","created":{"date-parts":[[2011,6,9]],"date-time":"2011-06-09T16:07:25Z","timestamp":1307635645000},"page":"63-69","source":"Crossref","is-referenced-by-count":33,"title":["Long-Term Outcome of Combined Interferon-\u03b1 and 5-Fluorouracil Treatment for Advanced Hepatocellular Carcinoma with Major Portal Vein Thrombosis"],"prefix":"10.1159","volume":"80","author":[{"given":"Hiroaki","family":"Nagano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Wada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shogo","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Marubashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetoshi","family":"Eguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Tanemura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshito","family":"Tomimaru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keigo","family":"Osuga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Umeshita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichiro","family":"Doki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,6,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0168-8278%2899%2980197-4"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0142%2819970601%2979%3A11%3C2087%3A%3AAID-CNCR5%3E3.0.CO%3B2-M"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0142%2819970515%2979%3A10%3C1890%3A%3AAID-CNCR8%3E3.0.CO%3B2-K"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159%2F000315244"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0142%2820000501%2988%3A9%3C1986%3A%3AAID-CNCR2%3E3.0.CO%3B2-I"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000048279"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2003.10.103"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.21832"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002%2Fhep.510310111"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1440-1746.2000.02289.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.10246"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.bjc.6602742"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00535-007-2028-x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.23033"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097%2F00000421-198212000-00014"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159%2F000227477"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097%2F00000658-200303000-00012"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00535-004-1494-7"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.22759"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1245%2Fs10434-010-1321-8"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.178.5.1655"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.onc.1202609"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1245%2FASO.2003.03.010"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1158%2F1078-0432.CCR-05-0274"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1186%2F1471-2407-9-361"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1158%2F1078-0432.CCR-04-0794"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jhep.2006.07.032"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1038%2Fnature01850"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.bjc.6604058"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1002%2Fhep.510290624"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1872-034X.2007.00007.x"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.bjc.6605064"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.bjc.6605669"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.23356"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1002%2Fhep.22506"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1158%2F1535-7163.MCT-06-0149"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2008.20.9908"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa0708857"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1245%2Fs10434-010-1310-y"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/328281","co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