{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:11:07Z","timestamp":1791094267328,"version":"4.1.0"},"reference-count":15,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Objectives:&lt;\/i&gt; While oral anticancer treatment has increased the convenience for patients with no risk of venous access complications compared to intravenous drug administration, a high level of compliance cannot always be assumed. The aim of the present report was to evaluate real-life drug adherence in a prospective cohort analysis of patients with gastrointestinal or breast cancer treated with capecitabine-based chemotherapy. &lt;i&gt;Methods:&lt;\/i&gt; Twenty-nine Swiss oncologists recruited patients receiving capecitabine, either as monotherapy or in combination with other chemotherapeutic agents, in a prospective fashion. Patients recorded both their capecitabine intake and any adverse effects each day in patient diaries. &lt;i&gt;Results:&lt;\/i&gt; A total of 177 patients were included, 143 (81%) with gastrointestinal tumours and 34 (19%) with breast cancer. Overall, 161 patients (91%) were considered as fully compliant, while 16 patients (9%) reported some kind of compliance error. Reasons for non-compliance included forgetting to take treatment (n = 9), side effects (n = 4) and misunderstanding instructions (n = 3). Self-reported compliance was not influenced by age or Eastern Cooperative Oncology Group performance status, but there was a trend towards better compliance with capecitabine therapy if fewer adverse effects occurred (p = 0.07, simple logistic regression). &lt;i&gt;Conclusions:&lt;\/i&gt; Self-reported compliance with capecitabine-based therapy in clinical practice is high and seems to be adversely affected by side effects.<\/jats:p>","DOI":"10.1159\/000328317","type":"journal-article","created":{"date-parts":[[2011,5,23]],"date-time":"2011-05-23T06:26:04Z","timestamp":1306131964000},"page":"29-33","source":"Crossref","is-referenced-by-count":54,"title":["Self-Reported Compliance with Capecitabine: Findings from a Prospective Cohort Analysis"],"prefix":"10.1159","volume":"80","author":[{"given":"Ralph","family":"Winterhalder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Hoesli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey","family":"Delmore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Pederiva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alb\u00e9ric","family":"Bressoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Hermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"von Moos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the SAEDA Investigators Group (Swiss prospective cohort group)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,5,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.bjc.6600591"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3322%2Fcaac.20004"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093%2Fannonc%2Fmdn646"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clinthera.2006.12.011"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038%2Fncponc1240"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2354.2006.00758.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1524-4733.2007.00213.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00280102"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038%2Fclpt.1989.121"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2009.26.4671"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.22485"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.1.6174.1335"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%2819860901%2958%3A5%3C1179%3A%3AAID-CNCR2820580534%3E3.0.CO%3B2-E"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.76.4.365"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10549-006-9193-0"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/328317","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/328317","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/328317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:20:01Z","timestamp":1745436001000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000328317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":15,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[2011,6,1]]},"published-print":{"date-parts":[[2011,6,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000328317","archive":["Portico"],"relation":{},"ISSN":["0030-2414","1423-0232"],"issn-type":[{"value":"0030-2414","type":"print"},{"value":"1423-0232","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}