{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:06:54Z","timestamp":1761059214803,"version":"3.40.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ORL"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; To evaluate the efficacy of long-term clarithromycin (CAM) treatment in adult Chinese patients suffering from chronic rhinosinusitis without nasal polyps (CRSnNP). &lt;i&gt;Methods:&lt;\/i&gt; Thirty-three CRSnNP patients were enrolled and subjected to CAM treatment for 12 weeks (250 mg daily). The total nasal symptom scores (TNSS), nasal resistance and inflammatory mediators including interleukin (IL)-8 and myeloperoxidase (MPO) were evaluated at weeks 0 and 12. Quality of life (QoL) was assessed in all patients by using the Sinonasal Outcome Test 20 and Short Form 36 questionnaires. &lt;i&gt;Results:&lt;\/i&gt; CAM treatment significantly improved TNSS, nasal resistance and QoL, and it inhibited IL-8 and MPO production in CRSnNP patients (p &lt; 0.05). CAM treatment was more effective for IL-8&lt;sup&gt;high&lt;\/sup&gt; CRSnNP patients than for IL-8&lt;sup&gt;low&lt;\/sup&gt; CRSnNP patients (p &lt; 0.05). &lt;i&gt;Conclusion:&lt;\/i&gt; Long-term, low-dose CAM treatment is effective and safe for the treatment of CRSnNP in Chinese patients.<\/jats:p>","DOI":"10.1159\/000328342","type":"journal-article","created":{"date-parts":[[2011,7,14]],"date-time":"2011-07-14T06:36:15Z","timestamp":1310625375000},"page":"206-211","source":"Crossref","is-referenced-by-count":22,"title":["Evaluation of Long-Term Clarithromycin Treatment in Adult Chinese Patients with Chronic Rhinosinusitis without Nasal 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