{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:09:43Z","timestamp":1761718183139,"version":"3.40.4"},"reference-count":21,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2011]]},"abstract":"<i>Aims:<\/i> To evaluate auxological parameters in children and adults with a 22q11.2 microdeletion syndrome (22q11.2 DS) and to compare prevalence of obesity to that in the French general population. <i>Methods:<\/i> 102 patients with 22q11.2 DS (49 males, 53 females) were recruited from birth to adulthood through a reference center in southern France. <i>Results:<\/i> Mean BMI Z score and mean height were normal (0.07 \u00b1 1.49 SD, \u20130.87 \u00b1 1.36 SDS, respectively). 16.1% of patients were overweight (including obese), 57% out of them being born small for gestational age for length versus 25% of non-overweight patients. During infancy, BMI increased in girls (+0.89 SD Z score). Childhood: 14.7% were overweight, prevalence similar to that of the in French children population. Adulthood: 19.2% were overweight. BMI Z scores were inversely correlated with neonatal length (p = 0.026) and female sex (p = 0.032) but positively associated with neonatal weight (p = 0.036). From analysis of neonatal data, 22q11.2 DS newborns were significantly shorter with regard to their weight (p < 0.01), even though mean neonatal measures were above \u20132 SDS. <i>Conclusions:<\/i> Our study did not find a higher prevalence of overweight in 22q11.2 DS to that in the French population. The BMI Z score was inversely correlated with neonatal length and female gender but positively associated with neonatal weight.<\/jats:p>","DOI":"10.1159\/000328454","type":"journal-article","created":{"date-parts":[[2011,8,9]],"date-time":"2011-08-09T14:05:52Z","timestamp":1312898752000},"page":"172-177","source":"Crossref","is-referenced-by-count":5,"title":["Auxological Evaluation in Patients with a 22q11.2 Microdeletion Syndrome: Normal Prevalence of Obesity and Neonatal Length and Gender Influence on Body Mass Index Evolution"],"prefix":"10.1159","volume":"76","author":[{"given":"R.","family":"Reynaud","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Derain-Court","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Braunstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Veyrat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Gaudart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Giuliano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Philip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,8,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.2003.026880"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1530%2Feje.1.02180"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1067%2Fmpd.2001.119448"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097%2F00125817-200101000-00005"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.101.5.929"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291096-8628%2819991008%2986%3A4%3C359%3A%3AAID-AJMG10%3E3.0.CO%3B2-V"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000086745"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136%2Fjmg.34.10.798"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ijcard.2006.02.042"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097%2F00125817-200101000-00007"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.320.7244.1240"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2869%2980224-6"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2307%2F2336267"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2307%2F2532642"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1001%2Farchinte.164.13.1413"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1467-789X.2010.00744.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1651-2227.2004.tb03024.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.gyobfe.2010.01.014"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.102.6.e72"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038%2Fijo.2009.31"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1080%2F08035250600719754"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/328454","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/328454","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:21:25Z","timestamp":1745436085000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000328454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":21,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,10,1]]},"published-print":{"date-parts":[[2011,9,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000328454","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"type":"print","value":"1663-2818"},{"type":"electronic","value":"1663-2826"}],"subject":[],"published":{"date-parts":[[2011]]}}}