{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T13:23:29Z","timestamp":1778937809022,"version":"3.51.4"},"reference-count":15,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2011,6,23]],"date-time":"2011-06-23T00:00:00Z","timestamp":1308787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,6,23]],"date-time":"2011-06-23T00:00:00Z","timestamp":1308787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; Glaucoma is the second leading cause of blindness worldwide. To date, several publications have evaluated the association between the tumor necrosis factor \u03b1 (TNF-\u03b1) \u2013308G\/A polymorphism and glaucoma risk. However, the results remain inconclusive. The aim of our study was to clarify the effect of the TNF-\u03b1 \u2013308G\/A polymorphism on glaucoma risk. &lt;i&gt;Method:&lt;\/i&gt; We conducted searches of the published literature in the PubMed database updated to May 2010. A meta-analysis was performed by critically reviewing 7 publications with a total of 1,199 glaucoma cases and 1,189 controls on the \u2013308G\/A polymorphism. Odds ratio (OR) and 95% confidence intervals (CIs) were used to assess the strength of this relationship. &lt;i&gt;Results:&lt;\/i&gt; Overall, no association between the TNF-\u03b1 \u2013308G\/A polymorphism and primary open-angle glaucoma or pseudoexfoliation glaucoma risk was found in the A allele versus G allele genetic model (OR = 1.68, 95% CI = 0.78\u20133.59 or OR = 2.44, 95% CI = 0.40\u201315.04, respectively), the same as genetic models in AG versus GG and AA + AG versus GG. In the stratified analysis by ethnicity and source of control subgroups, a significant association was still not observed in all genetic models. &lt;i&gt;Conclusion:&lt;\/i&gt; Our meta-analysis provides strong evidence that the TNF-\u03b1 \u2013308G\/A polymorphism is not associated with different forms of glaucoma risk.<\/jats:p>","DOI":"10.1159\/000328631","type":"journal-article","created":{"date-parts":[[2011,6,25]],"date-time":"2011-06-25T15:38:51Z","timestamp":1309016331000},"page":"47-51","source":"Crossref","is-referenced-by-count":5,"title":["A Detailed Meta-Analysis Shows No Association between TNF-\u03b1 \u2013308G\/A Polymorphism and Different Forms of Glaucoma"],"prefix":"10.1159","volume":"47","author":[{"given":"Qian-Qian","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,6,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1620%2Ftjem.221.1"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001%2Farchopht.122.7.1019"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.2005.081224"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0029%2820000801%2950%3A3%3C216%3A%3AAID-JEMT5%3E3.0.CO%3B2-Q"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2F1098-1136%28200010%2932%3A1%3C42%3A%3AAID-GLIA40%3E3.0.CO%3B2-3"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1167%2Fiovs.05-0299"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.metabol.2006.06.012"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007%2Fs12177-009-9026-6"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.eye.6700227"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1167%2Fiovs.03-1403"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159%2F000226108"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.eye.6702078"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2F0197-2456%2886%2990046-2"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1385%2FMN%3A26%3A1%3A045"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1167%2Fiovs.09-4974"}],"container-title":["Ophthalmic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/328631","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/328631","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/328631","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:22:56Z","timestamp":1745436176000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000328631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,23]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2011,12,1]]},"published-print":{"date-parts":[[2011,12,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000328631","archive":["Portico"],"relation":{},"ISSN":["0030-3747","1423-0259"],"issn-type":[{"value":"0030-3747","type":"print"},{"value":"1423-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,23]]}}}