{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T10:50:33Z","timestamp":1789901433191,"version":"4.0.1"},"reference-count":35,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebrovasc Dis"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Background and Objective:&lt;\/i&gt; Brachial arterial flow-mediated dilation (FMD) is associated with an increased risk of vascular events. Our aim was to investigate the relationship between FMD measured in the acute phase of ischemic stroke and a new major adverse vascular event in a consecutive cohort of patients followed up for 48 months after an acute first-ever stroke. &lt;i&gt;Methods:&lt;\/i&gt; We measured FMD in 120 consecutive patients with acute ischemic stroke using high-resolution ultrasonography. FMD was calculated as the relationship between the basal diameter of the brachial artery before and after transient vascular occlusion. Intima-media thickness, extracranial carotid atherosclerosis, stroke severity National Institute of Health Stroke Scale, and modified Rankin Scale at 3 months were also evaluated. A vascular event was defined as any of the following: vascular disease (VD) death, nonfatal myocardial infarction (MI), nonfatal recurrent stroke (RS), claudication or peripheral arterial thrombosis (PVD), angioplasty or cardiac bypass graft surgery. &lt;i&gt;Results:&lt;\/i&gt; There were 34 new major adverse vascular events in 32 of 120 patients (26.7%): 21 (61.8%) RS, 5 (14.7%) VD death, 5 (14.7%) MI, and 3 (8.8%) PVD. The presence of carotid artery plaque (81.3 vs. 46%; p &lt; 0.0001), atrial fibrillation (37.5 vs. 14.8%; p = 0.007) and FMD (5.30 \u00b1 7.48 vs. 10.54 \u00b1 7.02; p = 0.001) were associated with new-onset vascular events. FMD \u22644.5% was an independent predictor of new-onset vascular events (hazards ratio 3.48; 95% confidence interval 1.26\u20139.63; p = 0.01). &lt;i&gt;Conclusions:&lt;\/i&gt; FMD is an independent predictor for a new-onset vascular event after first-ever ischemic stroke.<\/jats:p>","DOI":"10.1159\/000328651","type":"journal-article","created":{"date-parts":[[2011,7,22]],"date-time":"2011-07-22T06:51:38Z","timestamp":1311317498000},"page":"155-162","source":"Crossref","is-referenced-by-count":40,"title":["Impaired Brachial Flow-Mediated Dilation Is a Predictor of a New-Onset Vascular Event after Stroke"],"prefix":"10.1159","volume":"32","author":[{"given":"Diego","family":"Santos-Garc\u00eda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"Serena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Rodr\u00edguez-Y\u00e1\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogelio","family":"Leira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Castillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,7,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.127.6.2254"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2803%2900994-X"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.106.678276"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.109.864801"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.atherosclerosis.2006.12.009"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1468-1331.2009.02564.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.20.7.864"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000054754"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.24.1.35"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159%2F000131083"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.290.17.2277"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000244763.19013.dc"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159%2F000097034"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2801%2901746-6"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097%2F00004872-200501000-00004"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000012543.55874.47"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2803%2900333-4"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2796.2006.01635.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0404.2006.00578.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1212%2F01.wnl.0000237526.32692.67"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000082382.42061.EE"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1159%2F000209260"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1159%2F000113864"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1159%2F000255973"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000254600.92975.1f"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.96.5.1432"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000226399.13528.0a"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016%2FS0741-5214%2800%2970066-8"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1159%2F000267847"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1161%2F01.ATV.0000051384.43104.FC"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1159%2F000089355"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1159%2F000226115"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.thromres.2007.09.008"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000152694.27996.3E"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-8703%2899%2970189-4"}],"container-title":["Cerebrovascular 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