{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:46:17Z","timestamp":1791276377731,"version":"4.1.0"},"reference-count":40,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathobiology"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; To evaluate the role of matrix metalloproteinase (MMP)-13 gene expression in the early phase of recovery from liver fibrosis\/cirrhosis. &lt;i&gt;Methods:&lt;\/i&gt; Liver fibrosis was induced in male Wistar rats by administration of carbon tetrachloride (CCl&lt;sub&gt;4&lt;\/sub&gt;) for 10 weeks. Recombinant adenovirus-mediated human MMP-13 gene transfer (RAdMMP-13) was performed via the femoral vein on day 3 after the last CCl&lt;sub&gt;4&lt;\/sub&gt; injection. The role of MMP-13 in stably expressing cell lines was also analyzed. &lt;i&gt;Results:&lt;\/i&gt; Fibrous deposition in the liver was decreased in RAdMMP-13-injected rats by day 3 after gene transfer compared with empty vector RAd66-injected rats. Furthermore, MMP-2 and MMP-9 enzymatic activity was markedly enhanced in the liver of RAdMMP-13 injected rats. Hepatocyte growth factor (HGF) induction was also increased in RAdMMP-13 injected rats. In established stable HT-1080 cells transfected with MMP-13, HGF-\u03b1 expression and MMP-2 and MMP-9 enzymatic activity were increased. The conversion of precursor HGF into mature HGF was also increased in the MMP-13 expressing cell lines. &lt;i&gt;Conclusion:&lt;\/i&gt; Forced MMP-13 expression effectively accelerated recovery from liver cirrhosis via the effects of MMP-13-mediated HGF, MMP-2, and MMP-9 expression, which induced the degradation of collagen fibers and promoted hepatic regeneration.<\/jats:p>","DOI":"10.1159\/000328841","type":"journal-article","created":{"date-parts":[[2011,8,17]],"date-time":"2011-08-17T02:19:16Z","timestamp":1313547556000},"page":"239-252","source":"Crossref","is-referenced-by-count":58,"title":["Matrix Metalloproteinase-13 Promotes Recovery from Experimental Liver Cirrhosis in 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