{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T10:51:19Z","timestamp":1779101479539,"version":"3.51.4"},"reference-count":33,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2011,8,11]],"date-time":"2011-08-11T00:00:00Z","timestamp":1313020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,8,11]],"date-time":"2011-08-11T00:00:00Z","timestamp":1313020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt;Vitamin D deficiency and protein-energy wasting (PEW) are highly prevalent in hemodialysis (HD) patients. The goal of our study was to investigate if a lack of vitamin D influences mortality and hospitalization of HD patients with or without PEW. &lt;i&gt;Methods:&lt;\/i&gt; In 81 chronic HD patients with different nutritional status assessed by the Malnutrition Inflammation Score (MIS), vitamin D deficiency (25-OH-vitamin D&lt;sub&gt;3&lt;\/sub&gt; levels \u226430 nmol\/l or \u226412 ng\/ml) was prospectively investigated for its prognostic impact on mortality and hospitalization. Over a 3-year follow-up, all-cause mortality and hospitalization were determined. The predictive value of low vitamin D levels and PEW as well as their combined effect were evaluated using a multivariate Cox regression model. &lt;i&gt;Results:&lt;\/i&gt; Vitamin D deficiency was frequent in HD patients with and without PEW. It significantly increased mortality rate in HD patients (HR 2.76 (1.33\u20135.73), p &lt; 0.01), which was aggravated by concomitant PEW (HR 5.88 (2.29\u201315.09), p &lt; 0.001). The hospitalization rate, however, was not influenced independently by nutritional status. &lt;i&gt;Conclusions:&lt;\/i&gt; Low 25-OH-vitamin D&lt;sub&gt;3&lt;\/sub&gt; concentration is an independent predictor for survival, but not for hospitalization of HD patients. It is not merely a malnutrition-associated finding, although a MIS \u22678 further impaired survival prognosis.<\/jats:p>","DOI":"10.1159\/000328927","type":"journal-article","created":{"date-parts":[[2011,8,11]],"date-time":"2011-08-11T11:26:43Z","timestamp":1313062003000},"page":"c220-c226","source":"Crossref","is-referenced-by-count":18,"title":["Vitamin D Deficiency, Mortality, and Hospitalization in Hemodialysis Patients with or without Protein-Energy 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