{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T11:29:45Z","timestamp":1787830185474,"version":"build-2784847793"},"reference-count":30,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[2011]]},"abstract":"<i>Background:<\/i><i>Escherichia coli<\/i> is known to produce enterotoxins whose properties and role in diarrheal disease have been extensively investigated; besides, this bacterium is related to several extra-intestinal problems in the intensive care unit and in surgical wound infections. Some species of <i>Staphylococcus<\/i> are recognized as etiological agents of opportunistic infections in animals and humans. This study is the first test on the modulation of antibiotic activity by <i>Croton campestris <\/i>A. against multiresistant strains of <i>E. coli<\/i> and <i>Staphylococcus aureus<\/i>. <i>Methods:<\/i> In this study, the hexane and methanol extract of <i>C. campestris <\/i>A. was tested for antibacterial activity alone and in combination with aminoglycosides against bacterial strains. The synergy of the methanol and hexane extract was verified by microdilution method. <i>Results:<\/i> A synergistic effect of both extracts combined with the aminoglycosides was demonstrated. <i>Conclusions:<\/i> It is suggested that the extracts from <i>C. campestris <\/i>A. could be used as a source of natural product derived from this plant with resistance-modifying antibacterial activity, providing a new weapon against the problem of bacterial resistance to antibiotics.<\/jats:p>","DOI":"10.1159\/000328975","type":"journal-article","created":{"date-parts":[[2011,7,20]],"date-time":"2011-07-20T10:04:28Z","timestamp":1311156268000},"page":"305-309","source":"Crossref","is-referenced-by-count":11,"title":["Phytochemical Prospection and Modulation of Aminoglycoside Antibiotic Activity by <i>Croton campestris <\/i>A."],"prefix":"10.1159","volume":"57","author":[{"given":"E.F.F.","family":"Matias","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.K.A.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.S.","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.G.M.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.D.M.","family":"Coutinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,7,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2880%2990510-3"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2F0041-0101%2882%2990210-0"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1186%2F1472-6882-9-13"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007%2Fs100960050324"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093%2Fjac%2F48.4.463"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jep.2004.11.016"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.fitote.2004.12.005"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0378-8741%2803%2900213-7"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000151267"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0261-2194%2802%2900095-9"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1021%2Fnp990292l"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186%2F1472-6882-7-9"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.fitote.2006.11.010"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.fct.2007.02.031"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1039%2Fb212695h"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cimid.2009.08.001"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0923-2508%2802%2901377-3"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1590%2FS0100-40422006000100021"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2006-961902"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1211%2F0022357011775389"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002%2F9780470123010.ch1"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2F0378-8741%2896%2985514-0"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1021%2Fnp50098a011"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002%2Fptr.1309"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1574-6968.1999.tb08733.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ijfoodmicro.2004.03.022"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1021%2Fjf980154m"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.phymed.2008.12.018"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1159%2F000140462"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1159%2F000226426"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/328975","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/328975","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/328975","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:25:29Z","timestamp":1745436329000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000328975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":30,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2011,9,1]]},"published-print":{"date-parts":[[2011,9,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000328975","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"value":"0009-3157","type":"print"},{"value":"1421-9794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}