{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:22:04Z","timestamp":1765545724153,"version":"3.40.4"},"reference-count":39,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychobiology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;i&gt;Aim:&lt;\/i&gt;In this study, we investigated serum protein levels of brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase B (TrkB) in patients with bipolar disorder. &lt;i&gt;Methods:&lt;\/i&gt;Over a 2-year period, 26 patients with bipolar I disorder (manic episode) and 56 healthy controls were recruited. The Young Mania Rating Scale scores of patients with bipolar mania were &gt;26. Serum BDNF and TrkB protein levels were measured with ELISA kits. &lt;i&gt;Results:&lt;\/i&gt; Using ANCOVA with age adjustment, we found that there were no significant differences in serum BDNF protein levels between patients with bipolar mania and healthy controls (p = 0.582). In contrast, the serum TrkB protein level was significantly higher in bipolar mania patients than in healthy controls (p = 0.001), especially in women (p = 0.001). Of 26 patients with bipolar mania, 21 underwent a second measurement of serum BDNF and TrkB protein levels after a 4-week treatment with mood stabilizers. There were no significant changes in serum BDNF or TrkB protein levels. &lt;i&gt;Conclusion:&lt;\/i&gt;These findings suggest that serum TrkB protein levels may play an important role in the psychopathology of bipolar mania. However, a larger sample size is needed to confirm these results.<\/jats:p>","DOI":"10.1159\/000328991","type":"journal-article","created":{"date-parts":[[2012,1,6]],"date-time":"2012-01-06T18:36:56Z","timestamp":1325875016000},"page":"65-69","source":"Crossref","is-referenced-by-count":20,"title":["Serum Protein Levels of Brain-Derived Neurotrophic Factor and Tropomyosin-Related Kinase B in Bipolar Disorder: Effects of Mood 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