{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T09:15:34Z","timestamp":1789722934140,"version":"4.0.1"},"reference-count":29,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2011,9,14]],"date-time":"2011-09-14T00:00:00Z","timestamp":1315958400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,9,14]],"date-time":"2011-09-14T00:00:00Z","timestamp":1315958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; The prevalence of chronic kidney disease (CKD) increases with age, but its significance in older patients is uncertain and is regarded by some as part of \u2018normal aging\u2019. Moreover, subjects \u226575 years are often excluded from research studies. We therefore undertook a prospective study of patients with CKD stage 3 in primary care to compare the risk profile of older versus younger subjects. &lt;i&gt;Methods:&lt;\/i&gt; Subjects with an estimated glomerular filtration rate (eGFR) 59\u201330 ml\/min\/1.73 m&lt;sup&gt;2&lt;\/sup&gt; on two measurements were recruited from 32 primary care practices. Medical history and demographic data were obtained and participants underwent clinical assessment as well as urine and serum biochemistry tests. &lt;i&gt;Results:&lt;\/i&gt; 1,741 participants were recruited: mean age 72.9 \u00b1 9 years; 60% female; 98% white; 17% diabetic. Mean eGFR was 52.5 \u00b1 10 ml\/min\/1.73 m&lt;sup&gt;2&lt;\/sup&gt; and 16.9% had albuminuria. Subjects \u226575 years had a significantly lower eGFR than younger subjects and a higher risk profile characterised by greater albuminuria, more arterial stiffness and higher serum uric acid levels. &lt;i&gt;Conclusion:&lt;\/i&gt; Older subjects with CKD stage 3 evidenced a higher risk profile for CKD progression and cardiovascular events than younger patients. This implies that CKD is not a benign condition in all elderly patients, but further investigation is required to identify those at greatest risk who may benefit from intervention.<\/jats:p>","DOI":"10.1159\/000329109","type":"journal-article","created":{"date-parts":[[2011,9,14]],"date-time":"2011-09-14T07:22:16Z","timestamp":1315984936000},"page":"c269-c276","source":"Crossref","is-referenced-by-count":23,"title":["Risk Profile in Chronic Kidney Disease Stage 3: Older versus Younger Patients"],"prefix":"10.1159","volume":"119","author":[{"given":"Natasha J.","family":"McIntyre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Fluck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher W.","family":"McIntyre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten W.","family":"Taal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,9,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ASN.0000070152.11927.4A"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.39001.657755.BE"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ASN.0000013291.78621.26"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.ajkd.2008.12.036"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093%2Fageing%2Fafm180"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfn086"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa041031"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2810%2960674-5"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2007040422"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2215%2FCJN.00070109"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa011161"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136%2Fjech.2003.013011"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0272-6386%2803%2900020-9"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.289.19.2560"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.99.18.2434"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2003.00932.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1161%2Fhy0202.098325"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097%2F01.hjh.0000234098.85497.31"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159%2F000320341"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.105.555235"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.109.886655"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jacc.2009.10.061"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1136%2Fhrt.2009.184879"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1161%2Fhy1001.096358"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.ajkd.2008.12.021"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1159%2F000084073"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.atherosclerosis.2008.05.022"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1253%2Fcircj.CJ-08-0828"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ki.5002374"}],"container-title":["Nephron Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/329109","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/329109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:16:30Z","timestamp":1745432190000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000329109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,14]]},"references-count":29,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2011,11,1]]},"published-print":{"date-parts":[[2011,11,25]]}},"URL":"https:\/\/doi.org\/10.1159\/000329109","archive":["Portico"],"relation":{},"ISSN":["1660-2110"],"issn-type":[{"value":"1660-2110","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,14]]}}}