{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T08:23:56Z","timestamp":1749889436729,"version":"3.40.4"},"reference-count":29,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2011,9,20]],"date-time":"2011-09-20T00:00:00Z","timestamp":1316476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,9,20]],"date-time":"2011-09-20T00:00:00Z","timestamp":1316476800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; We examined the potential of oral administration of nicorandil for protecting against cardiac death in hemodialysis patients without obstructive coronary artery disease. &lt;i&gt;Methods:&lt;\/i&gt; This study was based on a cohort study of 155 hemodialysis patients with angiographic absence of obstructive coronary lesions, with analysis performed in 100 propensity-matched patients (54 men and 46 women, 64 \u00b1 10 years), including 50 who received oral administration of nicorandil (15 mg\/day, nicorandil group) and 50 who did not (control). The efficacy of nicorandil in preventing cardiac death was investigated. &lt;i&gt;Results:&lt;\/i&gt; Over a mean follow-up period of 5.3 \u00b1 1.9 years, we observed 25 cardiac deaths among 100 propensity-matched patients, including 6 due to acute myocardial infarction, 11 due to heart failure, and 8 due to sudden cardiac death. The incidence of cardiac death was lower (p &lt; 0.001) in the nicorandil group (4\/50, 8%) than in the control (21\/50, 42%). On multivariate Cox hazard analysis, cardiac death was inversely associated with oral nicorandil (hazard ratio, 0.123; p = 0.0002). On Kaplan-Meier analysis, cardiac death-free survival rates at 5 years were higher in the nicorandil group than in the control group (91.4 vs. 66.4%). &lt;i&gt;Conclusion:&lt;\/i&gt; Oral nicorandil may inhibit cardiac death of hemodialysis patients without obstructive coronary artery disease.<\/jats:p>","DOI":"10.1159\/000329112","type":"journal-article","created":{"date-parts":[[2011,9,20]],"date-time":"2011-09-20T09:59:15Z","timestamp":1316512755000},"page":"c301-c309","source":"Crossref","is-referenced-by-count":5,"title":["Oral Nicorandil for Prevention of Cardiac Death in Hemodialysis Patients without Obstructive Coronary Artery Disease: A Propensity-Matched Patient Analysis"],"prefix":"10.1159","volume":"119","author":[{"given":"Masato","family":"Nishimura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chikako","family":"Sakoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayuko","family":"Murakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiko","family":"Tokoro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nodoka","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaya","family":"Nishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyuki","family":"Iwamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hakuo","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiko","family":"Ono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,9,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159%2F000209996"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1744-9987.2010.00893.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1525-139X.1989.tb00566.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfn426"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.2010.392"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1440-1681.1979.tb01252.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097%2F00005344-199104000-00016"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1161%2Fhc0302.102572"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2802%2908265-X"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159%2F000203074"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.ajkd.2009.03.025"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clinthera.2007.12.020"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jacc.2007.08.057"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2004.00808.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.2008.211"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00280883"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0258%2819981015%2917%3A19%3C2265%3A%3AAID-SIM918%3E3.0.CO%3B2-B"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1253%2Fcircj.68.232"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ahj.2005.06.030"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.yjmcc.2003.09.018"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.atherosclerosis.2010.11.032"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2004.00657.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2FS0033-0620%2805%2980050-7"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1994.182"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.106.647149"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ASN.0000130154.42061.C6"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9149%2862%2990098-X"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1097%2F00005344-199510000-00006"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016%2F0735-1097%2893%2990770-2"}],"container-title":["Nephron 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