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Karger AG","issue":"4","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Only few data are available on the efficacy of tigecycline in critically ill patients. &lt;i&gt;Methods:&lt;\/i&gt; This prospective, multicenter, non-interventional study investigated the efficacy and safety of tigecycline in hospitalized, severely ill patients with complicated intra-abdominal infections (cIAI) and\/or complicated skin and soft tissue infections (cSSTI). Documentation included diagnosis, clinical findings, Acute Physiology and Chronic Health Evaluation II score, laboratory assessments, surgery, clinical outcomes, and adverse events. &lt;i&gt;Results:&lt;\/i&gt; Six hundred and fifty-six patients (mean Acute Physiology and Chronic Health Evaluation II score 19.1) with cIAI (41%), cSSTI (16%), multiple infection sites (13%) and\/or other severe infections (31%) received tigecycline \u2013 51% as monotherapy \u2013 due to failure of previous antibiotics (55%) or since resistant pathogens were suspected or proven (45%); clinical cure\/improvement rates were 75, 82, 76 and 67% for cIAI, cSSTI, other severe infections and multiple infection sites, respectively. Drug-related adverse events occurred in 6.7% of patients. &lt;i&gt;Conclusions:&lt;\/i&gt; The efficacy and safety of tigecycline was demonstrated in a population of severely ill patients with complicated infections.<\/jats:p>","DOI":"10.1159\/000329406","type":"journal-article","created":{"date-parts":[[2011,7,21]],"date-time":"2011-07-21T08:04:02Z","timestamp":1311235442000},"page":"275-284","source":"Crossref","is-referenced-by-count":23,"title":["Prospective, Non-Interventional, Multi-Centre Trial of Tigecycline in the Treatment of Severely Ill Patients with Complicated Infections \u2013 New Insights into Clinical Results and Treatment Practice"],"prefix":"10.1159","volume":"57","author":[{"given":"Christian","family":"Eckmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang 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