{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:56:35Z","timestamp":1762505795375,"version":"3.40.4"},"reference-count":22,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Surg Res"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; In order to allow inflammatory response modification and ultimately improvement in tissue remodeling, we developed a new surface modification for meshes that will serve as a carrier for other substances. Biocompatibility is tested in an animal model. &lt;i&gt;Methods:&lt;\/i&gt; The animal model for diaphragmatic hernia repair was established in prior studies. Meshes were surface modified with star-configured PEO (polyethylene oxide)-based molecules [sP(EO-stat-PO)]. An electrospun nanoweb of short-term absorbable PLGA (polylactide-co-glycolide) with integrated sP(EO-stat-PO) molecules was applied onto the modified meshes. This coating also served as aerial sealing of the diaphragm. A final layer of hydrogel was applied to the product. Adhesive properties, defect size and mesh shrinkage were determined, and histological and immunohistochemical investigations performed after 4 months. &lt;i&gt;Results:&lt;\/i&gt; The mean defect size decreased markedly in both modified mesh groups. Histologically and with regard to apoptosis and proliferation rate, smooth muscle cells, collagen I\/III ratio and macrophage count, no statistically significant difference was seen between the 3 mesh groups. &lt;i&gt;Conclusions:&lt;\/i&gt; In this proof-of-principle investigation, we demonstrate good biocompatibility for this surface-modified mesh compared to a standard polypropylene-based mesh. This new coating represents a promising tool as a carrier for bioactive substances in the near future.<\/jats:p>","DOI":"10.1159\/000329412","type":"journal-article","created":{"date-parts":[[2011,7,20]],"date-time":"2011-07-20T10:04:28Z","timestamp":1311156268000},"page":"118-129","source":"Crossref","is-referenced-by-count":12,"title":["Biocompatibility of PLGA\/sP(EO-stat-PO)-Coated Mesh Surfaces under Constant Shearing Stress"],"prefix":"10.1159","volume":"47","author":[{"given":"Gabriele","family":"B\u00f6hm","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yelena","family":"Ushakova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamid Patrick","family":"Alizai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Till","family":"Braunschweig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Lente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl-Heinz","family":"Heffels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Groll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf Peter","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karsten","family":"Junge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,7,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3468%2898%2990522-X"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00383-004-1186-7"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.sempedsurg.2008.02.004"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jpedsurg.2005.10.005"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1053%2Fjpsu.2001.20037"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2008-1071226"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10029-004-0315-5"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00464-006-9147-y"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002%2Fsmll.200600596"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2Fmabi.200700064"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00268-002-6444-z"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00423-003-0429-8"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jss.2006.09.015"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00464-008-9923-y"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00464-006-9157-9"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10439-008-9608-7"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1163%2F156856206778366059"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.amjsurg.2006.06.045"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00464-005-0706-4"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00464-007-9737-3"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1159%2F000073389"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1159%2F000070045"}],"container-title":["European Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/329412","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/329412","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/329412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:19:37Z","timestamp":1745432377000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000329412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":22,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,10,1]]},"published-print":{"date-parts":[[2011,10,31]]}},"URL":"https:\/\/doi.org\/10.1159\/000329412","archive":["Portico"],"relation":{},"ISSN":["0014-312X","1421-9921"],"issn-type":[{"type":"print","value":"0014-312X"},{"type":"electronic","value":"1421-9921"}],"subject":[],"published":{"date-parts":[[2011]]}}}