{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T14:36:58Z","timestamp":1780670218066,"version":"3.54.1"},"reference-count":16,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2011,9,23]],"date-time":"2011-09-23T00:00:00Z","timestamp":1316736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,9,23]],"date-time":"2011-09-23T00:00:00Z","timestamp":1316736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2012]]},"abstract":"<i>Background:<\/i> Clara cell secretory protein (CCSP) is an anti-inflammatory mediator, but its role in neonatal lung adaptation and diseases is uncertain. <i>Objective:<\/i> To characterize postnatal changes in serum CCSP in relation to gestation, respiratory disease (RDS) and bronchopulmonary dysplasia (BPD) in comparison with other anti-inflammatory cytokines (IL-4, -10 and -13). <i>Methods:<\/i> Blood was collected from 76 infants (26 of 23\u201329 weeks\u2019 gestation, 33 of 30\u201336 weeks\u2019 gestation and 17 term infants) at birth (preterm cord blood); on admission; at 12, 24 and 48 h; and on days 3\u20134 and 7 of life. CCSP was assayed by ELISA and cytokines by Bio-Plex. <i>Results:<\/i> Median serum CCSP in extremely and moderately preterm infants rose from a baseline of 13.6 and 15.9 to 33.4 ng\/ml (p = 0.04) and 59.8 ng\/ml (p = 0.03) at 12 h of age, respectively. CCSP levels were highest in term infants (80.7 ng\/ml at 12 h). CCSP then decreased to 22.5 ng\/ml on days 3\u20134 (p = 0.001). CCSP of 37 RDS infants fell to a lower baseline on days 4 and 7 than that of the 22 non-RDS preterms. The 8 infants who developed BPD had persistently low serum CCSP (12.7 ng\/ml at 12 h). In contrast, early postnatal changes were not seen in IL-4, -10 and -13 levels, but low IL-10 and -13 levels were found on day 7 in BPD infants. <i>Conclusions:<\/i> Serum CCSP levels were characterized by an early postnatal surge. This apparent gestation-influenced surge may represent an initiation of a protective cascade against postnatal lung injury during extrauterine adaptation.<\/jats:p>","DOI":"10.1159\/000329557","type":"journal-article","created":{"date-parts":[[2011,9,23]],"date-time":"2011-09-23T14:54:05Z","timestamp":1316789645000},"page":"125-131","source":"Crossref","is-referenced-by-count":10,"title":["Early Postnatal Surge of Serum Clara Cell Secretory Protein in Newborn Infants"],"prefix":"10.1159","volume":"101","author":[{"given":"A.S.","family":"Loughran-Fowlds","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.W.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Oei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Michalowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Henry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Lui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,9,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2007-1444"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159%2F000285715"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159%2F000260136"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159%2F000297771"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159%2F000209301"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-199412000-00015"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002%2F1099-0496%28200012%2930%3A6%3C466%3A%3AAID-PPUL5%3E3.0.CO%3B2-X"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1203%2F01.pdr.0000219388.56608.77"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00431-008-0712-3"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00431-008-0713-2"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1651-2227.2002.tb00128.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186%2F1471-2431-3-8"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1006%2Fcyto.1997.0318"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159%2F000320170"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159%2F000253152"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1651-2227.2000.tb00768.x"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/329557","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/329557","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:20:51Z","timestamp":1745432451000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000329557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,23]]},"references-count":16,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,2,1]]},"published-print":{"date-parts":[[2012,2,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000329557","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,23]]}}}