{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T18:42:38Z","timestamp":1784054558354,"version":"3.55.0"},"reference-count":23,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2011]]},"abstract":"<i>Background:<\/i> The relationship between different paraoxonase <i>(PON)<\/i> gene polymorphisms and the risk of Alzheimer\u2019s disease (AD) was studied several times and the results were controversial. <i>Methods:<\/i> We investigated the association of 4 single-nucleotide polymorphisms (SNPs) of the <i>PON1<\/i> (M55L; Q192R; \u2013161C\/T) and the <i>PON2<\/i> (C311S) genes that were shown to affect the risk of sporadic AD. We studied 360 Caucasian cases with late-onset AD and 354 nondemented controls. <i>Results:<\/i> No significant differences were observed between the studied <i>PON<\/i> SNPs and AD risk. The results did not change after stratification of the apolipoprotein E status. Meta-analyses of studies in Caucasians assessing the associations between the <i>PON1 <\/i>M55L, \u2013161C\/T and Q192R SNPs and the risk of AD were performed, and no associations were found. <i>Conclusion:<\/i> Our results suggest that the studied <i>PON1<\/i> and <i>PON2<\/i> polymorphisms are not associated with late-onset AD.<\/jats:p>","DOI":"10.1159\/000329571","type":"journal-article","created":{"date-parts":[[2011,7,13]],"date-time":"2011-07-13T13:07:43Z","timestamp":1310562463000},"page":"417-423","source":"Crossref","is-referenced-by-count":7,"title":["Paraoxonase Gene Polymorphism and the Risk for Alzheimer\u2019s Disease in the Polish Population"],"prefix":"10.1159","volume":"31","author":[{"given":"A.","family":"Klimkowicz-Mrowiec","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Marona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Wolkow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Witkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Maruszak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Styczynska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Barcikowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Szczudlik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Slowik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,7,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1006%2Fgeno.1996.0225"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1161%2F01.ATV.21.4.473"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161%2F01.ATV.21.4.542"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0378-1119%2898%2900193-0"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1471-4159.2004.02959.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M004543200"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0021-9150%2898%2900071-9"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1600-0404.2001.103005304.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1749-6632.2002.tb04821.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj%2Fmp%2F4000916"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159%2F000067975"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3940%2802%2901437-4"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neulet.2006.08.074"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093%2Fhmg%2Fddi428"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neurobiolaging.2007.05.021"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2F0022-3956%2875%2990026-6"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1161%2F01.ATV.18.10.1611"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1042%2FCS19990239"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1749-6632.2002.tb04802.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004060200013"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jns.2009.02.317"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1159%2F000113709"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1460-9568.2009.06983.x"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/329571","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/329571","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:21:04Z","timestamp":1745432464000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000329571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":23,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2011,8,1]]},"published-print":{"date-parts":[[2011,8,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000329571","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}