{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:11:35Z","timestamp":1784851895754,"version":"3.55.0"},"reference-count":27,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2011,8,18]],"date-time":"2011-08-18T00:00:00Z","timestamp":1313625600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,8,18]],"date-time":"2011-08-18T00:00:00Z","timestamp":1313625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Exp Nephrol"],"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; Kidney disease patients experience declining calcitriol levels and develop secondary hyperparathyroidism (SHPT). Animal models of uremia based on 5\/6 nephrectomy (NTX) do not consistently reproduce this calcitriol deficiency. We developed an animal model, the NTX Cyp27b1-null mouse, which completely lacks endogenous calcitriol, and examined the suitability of this model for evaluation of treatment with vitamin D analogs in uremia. &lt;i&gt;Methods:&lt;\/i&gt; NTX was performed at 2 months of age. One week post-NTX, animals were treated for 4 weeks with vehicle; doxercalciferol at 30, 100 or 300 pg\/g body weight (b.w.); or paricalcitol at 100, 300 or 1,000 pg\/g b.w. by gavage 3 times per week. &lt;i&gt;Results:&lt;\/i&gt; Serum blood urea nitrogen and creatinine were elevated. Vehicle-treated NTX null mice had hypocalcemia and SHPT. Doxercalciferol at 100 or 300 pg\/g b.w. normalized serum calcium and parathyroid hormone (PTH) levels. Paricalcitol at 300 or 1,000 pg\/g normalized serum calcium, but PTH levels remained elevated. Osteomalacia was corrected by 100 pg\/g b.w. of doxercalciferol or 1,000 pg\/g b.w. of paricalcitol. The highest dose of doxercalciferol, but not of paricalcitol, significantly reduced osteitis fibrosa. &lt;i&gt;Conclusion:&lt;\/i&gt; Our results reveal the differential efficacy of doxercalciferol and paricalcitol in this novel animal model incorporating both calcitriol deficiency and renal insufficiency.<\/jats:p>","DOI":"10.1159\/000329663","type":"journal-article","created":{"date-parts":[[2011,8,18]],"date-time":"2011-08-18T06:46:48Z","timestamp":1313650008000},"page":"e67-e74","source":"Crossref","is-referenced-by-count":3,"title":["Differential Effects of Oral Doxercalciferol (Hectorol\u00ae) or Paricalcitol (Zemplar\u00ae) in the Cyp27b1-Null Mouse Model of Uremia"],"prefix":"10.1159","volume":"119","author":[{"given":"Ren\u00e9","family":"St-Arnaud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Arabian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Akhouayri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce C.","family":"Knutson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen A.","family":"Strugnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,8,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1359%2Fjbmr.2002.17.12.2094"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0272-6386%2897%2990330-9"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00467-004-1788-2"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.64.s87.17.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159%2F000072552"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000081787"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200005183422003"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2801%2901781-8"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.2215%2FCJN.02910707"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2F0272-6386%2895%2990455-7"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097%2F01.mnh.0000172720.34229.39"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2F13.suppl_3.68"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1053%2Fajkd.2000.16193"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0272-6386%2801%2980010-X"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0006-2952%2897%2900004-X"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ASN.0000133022.32912.95"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0272-6386%2897%2990571-0"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.142.7.3135"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2FS8756-3282%2803%2900023-1"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002%2Fjbmr.5650020617"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1525-139X.2005.18404.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.2005-0480"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1359%2Fjbmr.2003.18.4.637"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1053%2Fajkd.2001.29283"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1993.64"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfm094"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1089%2Fhum.2006.0101"}],"container-title":["Nephron Experimental Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/329663","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/329663","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:21:50Z","timestamp":1745432510000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000329663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,18]]},"references-count":27,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,10,1]]},"published-print":{"date-parts":[[2011,10,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000329663","archive":["Portico"],"relation":{},"ISSN":["1660-2129"],"issn-type":[{"value":"1660-2129","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,18]]}}}