{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T22:37:01Z","timestamp":1784759821093,"version":"3.55.0"},"reference-count":50,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Hepatic fibrosis is an integrated process triggered by chronic liver damage, leading to the accumulation of extracellular matrix. In patients with chronic liver disease, this process is favored by the presence of obesity or overweight, which are also relevant risk factors for the progression of nonalcoholic steatohepatitis. In this paper, we review the available evidence indicating the modulation of the fibrogenic process by adipokines, a group of cytokines secreted primarily by adipose tissue. In particular, we discuss in detail the role of leptin and adiponectin, which favor and limit the fibrogenic process, respectively. The possible involvement of other recently identified adipokines is also briefly outlined.<\/jats:p>","DOI":"10.1159\/000329799","type":"journal-article","created":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T21:38:52Z","timestamp":1492551532000},"page":"371-376","source":"Crossref","is-referenced-by-count":27,"title":["Modulation of Liver Fibrosis by Adipokines"],"prefix":"10.1159","volume":"29","author":[{"given":"Fabio","family":"Marra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Navari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Vivoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Galastri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Provenzano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,8,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.gastro.2008.03.003"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0168-8278%2802%2900263-5"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.molmed.2007.12.003"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2Fhep.20750"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2005.02.023"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2Fhep.23046"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.gastro.2003.11.020"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cld.2007.02.007"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMra011775"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.physbeh.2004.02.014"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jhep.2006.10.002"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1053%2Fgast.2002.32995"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.gastro.2009.04.011"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002%2Fhep.20965"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1053%2Fjhep.2002.32029"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS0006-291X%2802%2902300-8"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M308351200"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002%2Fhep.22515"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002%2Fhep.22560"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11010-009-0027-3"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.281.5383.1683"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI29126"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.2119%2F2008-00058.Rabe"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038%2Fnm1557"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.gastro.2007.04.068"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI200317797"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1002%2Fhep.21935"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.gastro.2003.08.029"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1440-1746.2009.06039.x"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jhep.2007.03.020"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1002%2Fhep.21995"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9440%2810%2962476-5"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1002%2Fhep.21991"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1146%2Fannurev.pharmtox.47.120505.105304"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1002%2Fhep.22365"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1038%2F35053000"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016%2FS0006-291X%2802%2902841-3"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.2337%2Fdiabetes.50.10.2199"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bbrc.2003.07.003"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1371%2Fjournal.pmed.0010045"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1093%2Femboj%2F19.15.4046"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.2353%2Fajpath.2006.060081"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M410078200"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1002%2Fart.22833"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-0030-1249059"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bbrc.2004.10.042"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.2004-1427"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1002%2Fhep.22467"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.2010-0754"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1016%2FS0168-8278%2811%2961038-6"}],"container-title":["Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/329799","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/329799","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:23:12Z","timestamp":1745432592000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000329799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":50,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2011,8,1]]},"published-print":{"date-parts":[[2011,8,31]]}},"URL":"https:\/\/doi.org\/10.1159\/000329799","archive":["Portico"],"relation":{},"ISSN":["0257-2753","1421-9875"],"issn-type":[{"value":"0257-2753","type":"print"},{"value":"1421-9875","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}